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The tunicate Ciona : a model system for understanding the relationship between regeneration and aging
(Taylor & Francis, 2014-06-10)
The use of the tunicate Ciona intestinalis as a model system to study the relationship between regeneration and aging is reviewed. Ciona has powerful regeneration capacities, which fade with age. Some additional benefits ...
Distal regeneration involves the age dependent activity of branchial sac stem cells in the ascidian Ciona intestinalis
(John Wiley & Sons, 2014-11-13)
Tunicates have high capacities for regeneration but the underlying mechanisms and their relationship to life cycle progression are not well understood. Here we investigate the regeneration of distal structures in the ...
Closing the wounds : one hundred and twenty five years of regenerative biology in the ascidian Ciona intestinalis
This year marks the 125th anniversary of the beginning of regeneration research in the ascidian Ciona intestinalis. A brief note was published in 1891 reporting the regeneration of the Ciona neural complex and siphons. ...
Kinesin family member 6 (kif6) is necessary for spine development in zebrafish
Idiopathic scoliosis is a form of spinal deformity that affects 2–3% of children and results in curvature of the spine without structural defects of the vertebral units. The pathogenesis of idiopathic scoliosis remains ...
Genome-wide identification of enhancer elements
(UPV/EHU Press, 2016-06)
We present a prospective genome-wide regulatory element database for the sea urchin embryo and the modified chromosome capture-related methodology used to create it. The method we developed is termed GRIP-seq for genome-wide ...
Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
(American Society for Cell Biology, 2014-10-01)
Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs synaptic vesicle trafficking. However, ...
Characterization of differential transcript abundance through time during Nematostella vectensis development
(BioMed Central, 2013-04-19)
Nematostella vectensis, a burrowing sea anemone, has become a popular species for the study of cnidarian development. In previous studies, the expression of a variety of genes has been characterized during N. vectensis ...
Cisplatin resistant spheroids model clinically relevant survival mechanisms in ovarian tumors
(Public Library of Science, 2016-03-17)
The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and ...