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Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
(American Society for Cell Biology, 2014-10-01)
Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs synaptic vesicle trafficking. However, ...
GRIPseq data for S. Purpuratus 24 hpf
This dataset is the result of a new method for identifying putative cis-regulatory elements genome wide, termed GRIPseq for Genome-wide Regulatory element Immunoprecipitation. Our protocol combines elements of chromatin ...
The amyloid precursor protein of Alzheimer’s disease clusters at the organelle/microtubule interface on organelles that bind microtubules in an ATP dependent manner
(Public Library of Science, 2016-01-27)
The amyloid precursor protein (APP) is a causal agent in the pathogenesis of Alzheimer’s disease and is a transmembrane protein that associates with membrane-limited organelles. APP has been shown to co-purify through ...
Evolution of the chordate regeneration blastema : differential gene expression and conserved role of notch signaling during siphon regeneration in the ascidian Ciona
The regeneration of the oral siphon (OS) and other distal structures in the ascidian Ciona intestinalis occurs by epimorphosis involving the formation of a blastema of proliferating cells. Despite the longstanding use of ...
Multi-jet propulsion organized by clonal development in a colonial siphonophore
(Nature Publishing Group, 2015-09-01)
Physonect siphonophores are colonial cnidarians that are pervasive predators in many neritic and oceanic ecosystems. Physonects employ multiple, clonal medusan individuals, termed nectophores, to propel an aggregate colony. ...
Microarray analysis of Xenopus endoderm expressing Ptf1a
Pancreas specific transcription factor 1a (Ptf1a), a bHLH transcription factor, has two temporally distinct functions during pancreas development; initially it is required for early specification of the entire pancreas, ...
A quantitative reference transcriptome for Nematostella vectensis early embryonic development : a pipeline for de novo assembly in emerging model systems
(BioMed Central, 2013-06-03)
The de novo assembly of transcriptomes from short shotgun sequences raises challenges due to random and non-random sequencing biases and inherent transcript complexity. We sought to define a pipeline for de novo transcriptome ...
A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis
(Society for Neuroscience, 2013-05-01)
Neurotransmission requires a continuously available pool of synaptic vesicles (SVs) that can fuse with the plasma membrane and release their neurotransmitter contents upon stimulation. After fusion, SV membranes and membrane ...