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Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton
(Rockefeller University Press, 2016-04-04)
Cells change shape in response to diverse environmental and developmental conditions, creating topologies with micron-scale features. Although individual proteins can sense nanometer-scale membrane curvature, it is unclear ...
Cisplatin resistant spheroids model clinically relevant survival mechanisms in ovarian tumors
(Public Library of Science, 2016-03-17)
The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and ...
Target detection in insects : optical, neural and behavioral optimizations
Motion vision provides important cues for many tasks. Flying insects, for example, may pursue small, fast moving targets for mating or feeding purposes, even when these are detected against self-generated optic flow. Since ...
Characterization of differential transcript abundance through time during Nematostella vectensis development
(BioMed Central, 2013-04-19)
Nematostella vectensis, a burrowing sea anemone, has become a popular species for the study of cnidarian development. In previous studies, the expression of a variety of genes has been characterized during N. vectensis ...
Novel structures associated with presumed photoreceptors in the aboral sense organ of ctenophores
(University of Chicago, 2016-10)
It is rare nowadays to find something that nobody has seen before, especially without using a new methodology or looking in a new place. Using conventional differential interference contrast (DIC) microscopy, I describe ...
How the bending kinematics of swimming lampreys build negative pressure fields for suction thrust
(Company of Biologists, 2016-12-14)
Swimming animals commonly bend their bodies to generate thrust. For undulating animals such as eels and lampreys, their bodies bend in the form of waves that travel from head to tail. These kinematics accelerate the flow ...
Suction-based propulsion as a basis for efficient animal swimming
(Nature Publishing Group, 2015-11-03)
A central and long-standing tenet in the conceptualization of animal swimming is the idea that propulsive thrust is generated by pushing the surrounding water rearward. Inherent in this perspective is the assumption that ...
Transcriptomic insights into genetic diversity of protein-coding genes in X. laevis
We characterize the genetic diversity of Xenopus laevis strains using RNA-seq data and allele- specific analysis. This data provides a catalogue of coding variation, which can be used for improving the genomic sequence, ...
An optimized method for cryogenic storage of Xenopus sperm to maximise the effectiveness of research using genetically altered frogs
Cryogenic storage of sperm from genetically altered Xenopus improves cost effectiveness and animal welfare associated with their use in research; currently it is routine for X. tropicalis but not reliable for X. laevis. ...