The ability of many animals to spontaneously regenerate their body parts has intrigued scientific observers for centuries. Although humans share the same basic genes and pathways, we have somehow lost these regenerative capacities, which leads to significant health costs. An understanding of tissue and organ regeneration in lower animals holds great promise for translating to medical treatments for serious human conditions, including spinal cord injury, diabetes, organ failure, and degenerative neural diseases such as Alzheimer’s.

Collections in this community

Recent Submissions

  • Modulation of G(q)/PLC-mediated signaling by acute lithium exposure 

    Sánchez Triviño, Cesar Adolfo; Landinez, Maria Paula; Duran, Sara; Gomez, Maria del Pilar; Nasi, Enrico (Frontiers Media, 2022-02-15)
    Although lithium has long been one of the most widely used pharmacological agents in psychiatry, its mechanisms of action at the cellular and molecular levels remain poorly understood. One of the targets of Li+ is the ...
  • Regulation of stem cell identity by miR-200a during spinal cord regeneration 

    Walker, Sarah E.; Sabin, Keith Z.; Gearhart, Micah D.; Yamamoto, Kenta (Company of Biologists, 2022-02-14)
    Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury and can also regenerate ...
  • Pupil dilation and constriction in the skate Leucoraja erinacea in a simulated natural light field 

    Mäthger, Lydia M.; Bok, Michael J.; Liebich, Jan; Sicius, Lucia; Nilsson, Dan-Eric (The Company of Biologists, 2022-02-14)
    The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient ...
  • Ramisyllis kingghidorahi n. Sp., a new branching annelid from Japan 

    Aguado, M. Teresa; Ponz-Segrelles, Guillermo; Glasby, Christopher J.; Ribeiro, Rannyele P.; Nakamura, Mayuko; Oguchi, Kohei; Omori, Akihito; Kohtsuka, Hisanori; Fischer, Christian; Ise, Yuji; Jimi, Naoto; Miura, Toru (Springer, 2022-01-19)
    Among over 20,000 species of Annelida, only two branching species with a highly modified body-pattern are known until now: the Syllidae Syllis ramosa McIntosh, 1879, and Ramisyllis multicaudata Glasby et al. (Zoological ...
  • Common environmental pollutants negatively affect development and regeneration in the sea anemone Nematostella vectensis holobiont 

    Klein, Sylvia; Frazier, Victoria; Readdean, Timothy; Lucas, Emily; Diaz-Jimenez, Erica P.; Sogin, Mitchell L.; Ruff, S. Emil; Echeverri, Karen (Frontiers Media, 2021-12-23)
    The anthozoan sea anemone Nematostella vectensis belongs to the phylum of cnidarians which also includes jellyfish and corals. Nematostella are native to United States East Coast marsh lands, where they constantly adapt ...
  • Uncovering the effects of symbiosis and temperature on coral calcification 

    Dellaert, Zoe; Vargas, Phillip A.; La Riviere, Patrick J.; Roberson, Loretta M. (University of Chicago Press, 2022-01-10)
    We tested the impact of temperature and symbiont state on calcification in corals, using the facultatively symbiotic coral Astrangia poculata as a model system. Symbiotic and aposymbiotic colonies of A. poculata were reared ...
  • Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods 

    Shoshan, Yoav; Liscovitch-Brauer, Noa; Rosenthal, Joshua J. C.; Eisenberg, Eli (Oxford University Press, 2021-05-22)
    RNA editing by the ADAR enzymes converts selected adenosines into inosines, biological mimics for guanosines. By doing so, it alters protein-coding sequences, resulting in novel protein products that diversify the proteome ...
  • Machine-learning-based evaluation of intratumoral heterogeneity and tumor-stroma interface for clinical guidance 

    Laurinavicius, Arvydas; Rasmusson, Allan; Plancoulaine, Benoit; Shribak, Michael; Levenson, Richard (Elsevier, 2021-09-21)
    Assessment of intratumoral heterogeneity and tumor-host interaction within the tumor microenvironment is becoming increasingly important for innovative cancer therapy decisions because of the unique information it can ...
  • Synuclein regulates synaptic vesicle clustering and docking at a vertebrate synapse 

    Fouke, Kaitlyn E.; Wegman, M. Elizabeth; Weber, Sarah A.; Brady, Emily B.; Román-Vendrell, Cristina; Morgan, Jennifer R. (Frontiers Media, 2021-11-26)
    Neurotransmission relies critically on the exocytotic release of neurotransmitters from small synaptic vesicles (SVs) at the active zone. Therefore, it is essential for neurons to maintain an adequate pool of SVs clustered ...
  • Survival and axonal outgrowth of the Mauthner cell following spinal cord crush does not drive post-injury startle responses 

    Zottoli, Steven J.; Faber, Donald S.; Hering, John; Dannhauer, Ann C.; Northen, Susan (Frontiers Media, 2021-11-19)
    A pair of Mauthner cells (M-cells) can be found in the hindbrain of most teleost fish, as well as amphibians and lamprey. The axons of these reticulospinal neurons cross the midline and synapse on interneurons and motoneurons ...
  • Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration 

    Fies, Jacob; Gemmell, Brad J.; Fogerson, Stephanie M.; Morgan, Jennifer R.; Tytell, Eric D.; Colin, Sean P. (The Company of Biologists, 2021-11-05)
    Axon regeneration is critical for restoring neural function after spinal cord injury. This has prompted a series of studies on the neural and functional recovery of lampreys after spinal cord transection. Despite this, ...
  • Deep learning is widely applicable to phenotyping embryonic development and disease 

    Naert, Thomas; Çiçek, Özgün; Ogar, Paulina; Bürgi, Max; Shaidani, Nikko-Ideen; Kaminski, Michael M.; Xu, Yuxiao; Grand, Kelli; Vujanovic, Marko; Prata, Daniel; Hildebrandt, Friedhelm; Brox, Thomas; Ronneberger, Olaf; Voigt, Fabian F.; Helmchen, Fritjof; Loffing, Johannes; Horb, Marko E.; Rankin Willsey, Helen; Lienkamp, Soeren S. (The Company of Biologists, 2021-11-05)
    Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how ...
  • The Nereid on the rise: Platynereis as a model system 

    Ozpolat, B. Duygu; Randel, Nadine; Williams, Elizabeth A.; Bezares-Calderón, Luis Alberto; Andreatta, Gabriele; Balavoine, Guillaume; Bertucci, Paola Y.; Ferrier, David E. K.; Gambi, Maria Cristina; Gazave, Eve; Handberg-Thorsager, Mette; Hardege, Jörg; Hird, Cameron; Hsieh, Yu-Wen; Hui, Jerome; Mutemi, Kevin Nzumbi; Schneider, Stephan Q.; Simakov, Oleg; Vergara, Hernando M.; Vervoort, Michel; Jékely, Gáspár; Tessmar-Raible, Kristin; Raible, Florian; Arendt, Detlev (BMC, 2021-09-27)
    The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195–269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a ...
  • Explaining regeneration: cells and limbs as complex living systems, learning from history 

    MacCord, Kate; Maienschein, Jane (Frontiers Media, 2021-08-31)
    Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within ...
  • Real-time polarization microscopy of fibrillar collagen in histopathology 

    Keikhosravi, Adib; Shribak, Michael; Conklin, Matthew W.; Liu, Yuming; Li, Bin; Loeffler, Agnes; Levenson, Richard; Eliceiri, Kevin (Nature Research, 2021-09-24)
    Over the past two decades, fibrillar collagen reorganization parameters such as the amount of collagen deposition, fiber angle and alignment have been widely explored in numerous studies. These parameters are now widely ...
  • Corals regulate the distribution and abundance of Symbiodiniaceae and biomolecules in response to changing water depth and sea surface temperature 

    Sivaguru, Mayandi; Todorov, Lauren G.; Fouke, Courtney E.; Munro, Cara M. O.; Fouke, Kyle W.; Fouke, Kaitlyn E.; Baughman, Melinda E.; Fouke, Bruce W. (Nature Research, 2021-01-26)
    The Scleractinian corals Orbicella annularis and O. faveolata have survived by acclimatizing to environmental changes in water depth and sea surface temperature (SST). However, the complex physiological mechanisms by which ...
  • Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy 

    Vitkunaite, Aiste; Laurinaviciene, Aida; Plancoulaine, Benoit; Rasmusson, Allan; Levenson, Richard; Shribak, Michael; Laurinavicius, Arvydas (Nature Research, 2021-03-18)
    Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes ...
  • Oxygen supply capacity breathes new life into critical oxygen partial pressure (Pcrit) 

    Seibel, Brad A.; Andres, Alyssa; Birk, Matthew A.; Burns, Alexandra L.; Shaw, C. Tracy; Timpe, Alexander W.; Welsh, Christina J. (The Company of Biologists, 2021-04-30)
    The critical oxygen partial pressure (Pcrit), typically defined as the PO2 below which an animal's metabolic rate (MR) is unsustainable, is widely interpreted as a measure of hypoxia tolerance. Here, Pcrit is defined as ...
  • Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning 

    Tani, Tomomi; Koike-Tani, Maki; Tran, Mai Thi; Shribak, Michael; Levic, Snezana (Nature Research, 2021-04-07)
    The basilar membrane (BM) of the mammalian cochlea constitutes a spiraling acellular ribbon that is intimately attached to the organ of Corti. Its graded stiffness, increasing from apex to the base of the cochlea provides ...
  • Effects of excess brain-derived human alpha-synuclein on synaptic vesicle trafficking 

    Román-Vendrell, Cristina; Medeiros, Audrey T.; Sanderson, John B.; Jiang, Haiyang; Bartels, Tim; Morgan, Jennifer R. (Frontiers Media, 2021-02-04)
    α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and ...

View more