The ability of many animals to spontaneously regenerate their body parts has intrigued scientific observers for centuries. Although humans share the same basic genes and pathways, we have somehow lost these regenerative capacities, which leads to significant health costs. An understanding of tissue and organ regeneration in lower animals holds great promise for translating to medical treatments for serious human conditions, including spinal cord injury, diabetes, organ failure, and degenerative neural diseases such as Alzheimer’s.

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  • The evolution of synaptic and cognitive capacity: insights from the nervous system transcriptome of Aplysia 

    Orvis, Joshua; Albertin, Carolin B.; Shrestha, Pragya; Chen, Shuangshuang; Zheng, Melanie; Rodriguez, Cheyenne J.; Tallon, Luke J.; Mahurkar, Anup; Zimin, Aleksey V.; Kim, Michelle; Liu, Kelvin; Kandel, Eric R.; Fraser, Claire M.; Sossin, Wayne; Abrams, Thomas W. (National Academy of Sciences, 2022-07-08)
    The gastropod mollusk Aplysia is an important model for cellular and molecular neurobiological studies, particularly for investigations of molecular mechanisms of learning and memory. We developed an optimized assembly ...
  • Normal table of Xenopus development: a new graphical resource 

    Zahn, Natalya; James-Zorn, Christina; Ponferrada, Virgilio G.; Adams, Dany S.; Grzymkowski, Julia; Buchholz, Daniel R.; Nascone-Yoder, Nanette M.; Horb, Marko E.; Moody, Sally A.; Vize, Peter D.; Zorn, Aaron M. (The Company of Biologists, 2022-07-14)
    Normal tables of development are essential for studies of embryogenesis, serving as an important resource for model organisms, including the frog Xenopus laevis. Xenopus has long been used to study developmental and cell ...
  • Developing immortal cell lines from Xenopus embryos, four novel cell lines derived from Xenopus tropicalis 

    Gorbsky, Gary J.; Daum, John R.; Sapkota, Hem; Summala, Katja; Yoshida, Hitoshi; Georgescu, Constantin; Wren, Jonathan D.; Peshkin, Leonid; Horb, Marko E. (The Royal Society, 2022-07-06)
    The diploid anuran Xenopus tropicalis has emerged as a key research model in cell and developmental biology. To enhance the usefulness of this species, we developed methods for generating immortal cell lines from Nigerian ...
  • Point spread function of the polarized light field microscope 

    Tran, Mai Thi; Oldenbourg, Rudolf (Optica, 2022-05-26)
    We examined the point spread function of the polarized light field microscope and established a computational framework to solve the forward problem in polarized light field imaging, for the purpose of furthering its use ...
  • An experimental method for evoking and characterizing dynamic color patterning of cuttlefish during prey capture 

    Kim, Danbee; Buresch, Kendra C.; Hanlon, Roger T.; Kampff, Adam R. (POL Scientific, 2022-06-14)
    Cuttlefish are active carnivores that possess a wide repertoire of body patterns that can be changed within milliseconds for many types of camouflage and communication. The forms and functions of many body patterns are ...
  • Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse 

    Pattanayak, Rudradip; Underwood, Rachel; Crowley, Michael R.; Crossman, David K.; Morgan, Jennifer R.; Yacoubian, Talene A. (Nature Research, 2022-06-14)
    We report an incidental 358.5 kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double knockout (DKO) mouse line previously developed by Tolmachova and colleagues ...
  • Spinal cord regeneration—the origins of progenitor cells for functional rebuilding 

    Walker, Sarah E.; Echeverri, Karen (Elsevier, 2022-05-24)
    The spinal cord is one of the most important structures for all vertebrate animals as it connects almost all parts of the body to the brain. Injury to the mammalian spinal cord has devastating consequences, resulting in ...
  • Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain 

    Petrosino, Giuseppe; Ponte, Giovanna; Volpe, Massimiliano; Zarrella, Ilaria; Ansaloni, Federico; Langella, Concetta; Di Cristina, Giulia; Finaurini, Sara; Russo, Monia T.; Basu, Swaraj; Musacchia, Francesco; Ristoratore, Filomena; Pavlinic, Dinko; Benes, Vladimir; Ferrante, Maria I.; Albertin, Carolin B.; Simakov, Oleg; Gustincich, Stefano; Sanges, Remo (BMC, 2022-05-18)
    Background Transposable elements (TEs) widely contribute to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity, and giving birth to long non-coding RNAs (lncRNAs). These ...
  • Endogenous retroviruses augment amphibian (Xenopus laevis) tadpole antiviral protection 

    Kalia, Namarta; Hauser, Kelsey A.; Burton, Sarah; Hossainey, Muhammad Riadul Haque; Zelle, Mira; Horb, Marko E.; Grayfer, Leon (American Society for Microbiology, 2022-05-16)
    The global amphibian declines are compounded by infections with members of the Ranavirus genus such as Frog Virus 3 (FV3). Premetamorphic anuran amphibians are believed to be significantly more susceptible to FV3 while ...
  • Genome and transcriptome mechanisms driving cephalopod evolution 

    Albertin, Carolin B.; Medina-Ruiz, Sofia; Mitros, Therese; Schmidbaur, Hannah; Sanchez, Gustavo; Wang, Z. Yan; Grimwood, Jane; Rosenthal, Joshua J. C.; Ragsdale, Clifton W.; Simakov, Oleg; Rokhsar, Daniel S. (Nature Research, 2022-05-04)
    Cephalopods are known for their large nervous systems, complex behaviors and morphological innovations. To investigate the genomic underpinnings of these features, we assembled the chromosomes of the Boston market squid, ...
  • Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization 

    Schmidbaur, Hannah; Kawaguchi, Akane; Clarence, Tereza; Fu, Xiao; Hoang, Oi Pui; Zimmermann, Bob; Ritschard, Elena A.; Weissenbacher, Anton; Foster, Jamie S.; Nyholm, Spencer V.; Bates, Paul A.; Albertin, Carolin B.; Tanaka, Elly; Simakov, Oleg (Nature Research, 2022-04-21)
    Coleoid cephalopods (squid, cuttlefish, octopus) have the largest nervous system among invertebrates that together with many lineage-specific morphological traits enables complex behaviors. The genomic basis underlying ...
  • Activating transcription factor 3 (ATF3) is a highly conserved pro-regenerative transcription factor in the vertebrate nervous system 

    Katz, Hilary R.; Arcese, Anthony A.; Bloom, Ona E.; Morgan, Jennifer R. (Frontiers Media, 2022-03-08)
    The vertebrate nervous system exhibits dramatic variability in regenerative capacity across species and neuronal populations. For example, while the mammalian central nervous system (CNS) is limited in its regenerative ...
  • Advances in genome editing tools 

    Horb, Marko E.; Abu-Daya, Anita; Wlizla, Marcin; Noble, Anna; Guille, Matthew (Taylor & Francis, 2022-04-19)
    This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge ...
  • Modulation of G(q)/PLC-mediated signaling by acute lithium exposure 

    Sánchez Triviño, Cesar Adolfo; Landinez, Maria Paula; Duran, Sara; Gomez, Maria del Pilar; Nasi, Enrico (Frontiers Media, 2022-02-15)
    Although lithium has long been one of the most widely used pharmacological agents in psychiatry, its mechanisms of action at the cellular and molecular levels remain poorly understood. One of the targets of Li+ is the ...
  • Regulation of stem cell identity by miR-200a during spinal cord regeneration 

    Walker, Sarah E.; Sabin, Keith Z.; Gearhart, Micah D.; Yamamoto, Kenta (Company of Biologists, 2022-02-14)
    Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury and can also regenerate ...
  • Pupil dilation and constriction in the skate Leucoraja erinacea in a simulated natural light field 

    Mäthger, Lydia M.; Bok, Michael J.; Liebich, Jan; Sicius, Lucia; Nilsson, Dan-Eric (The Company of Biologists, 2022-02-14)
    The skate Leucoraja erinacea has an elaborately shaped pupil, whose characteristics and functions have received little attention. The goal of our study was to investigate the pupil response in relation to natural ambient ...
  • Ramisyllis kingghidorahi n. Sp., a new branching annelid from Japan 

    Aguado, M. Teresa; Ponz-Segrelles, Guillermo; Glasby, Christopher J.; Ribeiro, Rannyele P.; Nakamura, Mayuko; Oguchi, Kohei; Omori, Akihito; Kohtsuka, Hisanori; Fischer, Christian; Ise, Yuji; Jimi, Naoto; Miura, Toru (Springer, 2022-01-19)
    Among over 20,000 species of Annelida, only two branching species with a highly modified body-pattern are known until now: the Syllidae Syllis ramosa McIntosh, 1879, and Ramisyllis multicaudata Glasby et al. (Zoological ...
  • Common environmental pollutants negatively affect development and regeneration in the sea anemone Nematostella vectensis holobiont 

    Klein, Sylvia; Frazier, Victoria; Readdean, Timothy; Lucas, Emily; Diaz-Jimenez, Erica P.; Sogin, Mitchell L.; Ruff, S. Emil; Echeverri, Karen (Frontiers Media, 2021-12-23)
    The anthozoan sea anemone Nematostella vectensis belongs to the phylum of cnidarians which also includes jellyfish and corals. Nematostella are native to United States East Coast marsh lands, where they constantly adapt ...
  • Uncovering the effects of symbiosis and temperature on coral calcification 

    Dellaert, Zoe; Vargas, Phillip A.; La Riviere, Patrick J.; Roberson, Loretta M. (University of Chicago Press, 2022-01-10)
    We tested the impact of temperature and symbiont state on calcification in corals, using the facultatively symbiotic coral Astrangia poculata as a model system. Symbiotic and aposymbiotic colonies of A. poculata were reared ...
  • Adaptive proteome diversification by nonsynonymous A-to-I RNA editing in coleoid cephalopods 

    Shoshan, Yoav; Liscovitch-Brauer, Noa; Rosenthal, Joshua J. C.; Eisenberg, Eli (Oxford University Press, 2021-05-22)
    RNA editing by the ADAR enzymes converts selected adenosines into inosines, biological mimics for guanosines. By doing so, it alters protein-coding sequences, resulting in novel protein products that diversify the proteome ...

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