The ability of many animals to spontaneously regenerate their body parts has intrigued scientific observers for centuries. Although humans share the same basic genes and pathways, we have somehow lost these regenerative capacities, which leads to significant health costs. An understanding of tissue and organ regeneration in lower animals holds great promise for translating to medical treatments for serious human conditions, including spinal cord injury, diabetes, organ failure, and degenerative neural diseases such as Alzheimer’s.

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  • Recovery of burrowing behavior after spinal cord injury in the larval sea lamprey 

    Katz, Hilary R.; Fouke, Kaitlyn E.; Losurdo, Nicole A.; Morgan, Jennifer R. (University of Chicago Press, 2020-10-27)
    Following traumatic spinal cord injury, most mammalian species are unable to achieve substantial neuronal regeneration and often experience loss of locomotor function. In contrast, larval sea lampreys (Petromyzon marinus) ...
  • A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome 

    Furman, Benjamin L. S.; Cauret, Caroline M. S.; Knytl, Martin; Song, Xue-Ying; Premachandra, Tharindu; Ofori-Boateng, Caleb; Jordan, Danielle C.; Horb, Marko E.; Evans, Ben J. (Public Library of Science, 2020-11-09)
    In many species, sexual differentiation is a vital prelude to reproduction, and disruption of this process can have severe fitness effects, including sterility. It is thus interesting that genetic systems governing sexual ...
  • The role of suction thrust in the metachronal paddles of swimming invertebrates 

    Colin, Sean P.; Costello, John H.; Sutherland, Kelly R.; Gemmell, Brad J.; Dabiri, John O.; Du Clos, Kevin T. (Nature Research, 2020-10-20)
    An abundance of swimming animals have converged upon a common swimming strategy using multiple propulsors coordinated as metachronal waves. The shared kinematics suggest that even morphologically and systematically diverse ...
  • Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network 

    Mukherjee, Shreyasi; Chaturvedi, Praneet; Rankin, Scott A.; Fish, Margaret B.; Wlizla, Marcin; Paraiso, Kitt D.; MacDonald, Melissa; Chen, Xiaoting; Weirauch, Matthew T.; Blitz, Ira L.; Cho, Ken W. Y.; Zorn, Aaron M. (eLife Sciences Publications, 2020-09-07)
    Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive ...
  • CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis 

    Wiechmann, Allan F.; Martin, Teryn A.; Horb, Marko E. (Nature Research, 2020-08-13)
    Nighttime surges in melatonin levels activate melatonin receptors, which synchronize cellular activities with the natural light/dark cycle. Melatonin receptors are expressed in several cell types in the retina, including ...
  • Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos 

    Naert, Thomas; Tulkens, Dieter; Edwards, Nicole A.; Carron, Marjolein; Shaidani, Nikko-Ideen; Wlizla, Marcin; Boel, Annekatrien; Demuynck, Suzan; Horb, Marko E.; Coucke, Paul; Willaert, Andy; Zorn, Aaron M.; Vleminckx, Kris (Nature Research, 2020-09-04)
    CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes ...
  • α-Synuclein-112 impairs synaptic vesicle recycling consistent with its enhanced membrane binding properties 

    Soll, Lindsey G.; Eisen, Julia N.; Vargas, Karina J.; Medeiros, Audrey T.; Hammar, Katherine M.; Morgan, Jennifer R. (Frontiers Media, 2020-05-29)
    Synucleinopathies are neurological disorders associated with α-synuclein overexpression and aggregation. While it is well-established that overexpression of wild type α-synuclein (α-syn-140) leads to cellular toxicity and ...
  • Long-term imaging of the photosensitive, reef-building coral Acropora muricata using light-sheet illumination 

    Laissue, Pierre Philippe; Roberson, Loretta M.; Gu, Yan; Qian, Chen; Smith, David J. (Nature Research, 2020-06-25)
    Coral reefs are in alarming decline due to climate emergency, pollution and other man-made disturbances. The numerous ecosystem services derived from coral reefs are underpinned by the growth and physical complexity of ...
  • The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum 

    Freire, Isabel; Gutner-Hoch, Eldad; Muras, Andrea; Benayahu, Yehuda; Otero, Ana (Public Library of Science, 2019-09-30)
    While increasing evidence supports a key role of bacteria in coral larvae settlement and development, the relative importance of environmentally-acquired versus vertically-transferred bacterial population is not clear. ...
  • Wound healing across the animal kingdom: Crosstalk between the immune system and the extracellular matrix 

    Arenas Gómez, Claudia Marcela; Sabin, Keith Z.; Echeverri, Karen (Wiley, 2020-04-20)
    Tissue regeneration is widespread in the animal kingdom. To date, key roles for different molecular and cellular programs in regeneration have been described, but the ultimate blueprint for this talent remains elusive. In ...
  • Radial alignment of microtubules through tubulin polymerization in an evaporating droplet 

    Keya, Jakia Jannat; Kudoh, Hiroki; Kabir, Arif Md. Rashedul; Inoue, Daisuke; Miyamoto, Nobuyoshi; Tani, Tomomi; Kakugo, Akira; Shikinaka, Kazuhiro (Public Library of Science, 2020-04-10)
    We report the formation of spherulites from droplets of highly concentrated tubulin solution via nucleation and subsequent polymerization to microtubules (MTs) under water evaporation by heating. Radial alignment of MTs ...
  • Spatially regulated editing of genetic information within a neuron 

    Vallecillo-Viejo, Isabel C.; Liscovitch-Brauer, Noa; Diaz Quiroz, Juan F.; Montiel-González, Maria Fernanda; Nemes, Sonya E.; Rangan, Kavita J.; Levinson, Simon R.; Eisenberg, Eli; Rosenthal, Joshua J. C. (Oxford University Press, 2020-03-23)
    In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can ...
  • FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells 

    Smith, Jean A.; Curry, Ennessa G.; Blue, R. Eric; Roden, Christine; Dundon, Samantha E.R.; Rodríguez-Vargas, Anthony; Jordan, Danielle C.; Chen, Xiaomin; Lyons, Shawn M.; Crutchley, John M.; Anderson, Paul; Horb, Marko E.; Gladfelter, Amy S.; Giudice, Jimena (Rockefeller University Press, 2020-03-13)
    Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes ...
  • A de novo reference transcriptome for Bolitoglossa vallecula, an Andean mountain salamander in Colombia 

    Arenas Gómez, Claudia Marcela; Woodcock, M. Ryan; Smith, Jeramiah J.; Voss, S. Randal; Delgado, Jean Paul (Elsevier, 2020-02-11)
    The amphibian order Caudata, contains several important model species for biological research. However, there is need to generate transcriptome data from representative species of the primary salamander families. Here we ...
  • 12-h clock regulation of genetic information flow by XBP1s 

    Pan, Yinghong; Ballance, Heather; Meng, Huan; Gonzalez, Naomi; Kim, Sam-Moon; Abdurehman, Leymaan; York, Brian; Chen, Xi; Schnytzer, Yisrael; Levy, Oren; Dacso, Clifford C.; McClung, Colleen A.; O’Malley, Bert W.; Liu, Silvia; Zhu, Bokai (Public Library of Science, 2020-01-14)
    Our group recently characterized a cell-autonomous mammalian 12-h clock independent from the circadian clock, but its function and mechanism of regulation remain poorly understood. Here, we show that in mouse liver, ...
  • The various routes to functional regeneration in the central nervous system 

    Echeverri, Karen (Nature Research, 2020-01-29)
    The axolotl is a type of Mexican salamander with astonishing regenerative capacity1. In our recent paper, we identified a signaling heterodimer that is formed directly after injury in the glial cells adjacent to the injury ...
  • A draft genome sequence of the elusive giant squid, Architeuthis dux 

    da Fonseca, Rute R.; Couto, Alvarina; Machado, Andre M.; Brejova, Brona; Albertin, Carolin B.; Silva, Filipe; Gardner, Paul; Baril, Tobias; Hayward, Alex; Campos, Alexandre; Ribeiro, Ângela M.; Barrio-Hernandez, Inigo; Hoving, Henk-Jan; Tafur-Jimenez, Ricardo; Chu, Chong; Frazão, Barbara; Petersen, Bent; Peñaloza, Fernando; Musacchia, Francesco; Alexander, Graham C., Jr.; Osório, Hugo; Winkelmann, Inger; Simakov, Oleg; Rasmussen, Simon; Rahman, M. Ziaur; Pisani, Davide; Vinther, Jakob; Jarvis, Erich; Zhang, Guojie; Strugnell, Jan M.; Castro, L. Filipe C.; Fedrigo, Olivier; Patricio, Mateus; Li, Qiye; Rocha, Sara; Antunes, Agostinho; Wu, Yufeng; Ma, Bin; Sanges, Remo; Vinar, Tomas; Blagoev, Blagoy; Sicheritz-Ponten, Thomas; Nielsen, Rasmus; Gilbert, M. Thomas P. (Oxford University Press, 2020-01-16)
    Background: The giant squid (Architeuthis dux; Steenstrup, 1857) is an enigmatic giant mollusc with a circumglobal distribution in the deep ocean, except in the high Arctic and Antarctic waters. The elusiveness of the ...
  • Hsc70 ameliorates the vesicle recycling defects caused by excess alpha-synuclein at synapses 

    Banks, Susan M. L.; Medeiros, Audrey T.; McQuillan, Molly; Busch, David J.; Ibarraran-Viniegra, Ana Sofia; Sousa, Rui; Lafer, Eileen M.; Morgan, Jennifer R. (Society for Neuroscience, 2020-01-15)
    α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein ...
  • Specialization for rapid excitation in fast squid tentacle muscle involves action potentials absent in slow arm muscle 

    Gilly, William; Renken, Corbin; Rosenthal, Joshua J. C.; Kier, William M. (Company of Biologists, 2020-01-03)
    An important aspect of the performance of many fast muscle fiber types is rapid excitation. Previous research on the cross-striated muscle fibers responsible for the rapid tentacle strike in squid has revealed the ...
  • A scalable culturing system for the marine annelid Platynereis dumerilii 

    Kuehn, Emily; Stockinger, Alexander W.; Girard, Jerome; Raible, Florian; Ozpolat, B. Duygu (Public Library of Science, 2019-12-05)
    Platynereis dumerilii is a marine segmented worm (annelid) with externally fertilized embryos and it can be cultured for the full life cycle in the laboratory. The accessibility of embryos and larvae combined with the ...

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