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dc.contributor.authorLasek-Nesselquist, Erica
dc.contributor.authorBogomolni, Andrea L.
dc.contributor.authorGast, Rebecca J.
dc.contributor.authorMark Welch, David B.
dc.contributor.authorEllis, Julie C.
dc.contributor.authorSogin, Mitchell L.
dc.contributor.authorMoore, Michael J.
dc.date.accessioned2011-04-08T18:08:10Z
dc.date.available2011-04-08T18:08:10Z
dc.date.issued2008-08-19
dc.identifier.citationDiseases of Aquatic Organisms 81 (2008): 39-51en_US
dc.identifier.urihttp://hdl.handle.net/1912/4448
dc.descriptionAuthor Posting. © Inter-Research, 2008. This article is posted here by permission of Inter-Research for personal use, not for redistribution. The definitive version was published in Diseases of Aquatic Organisms 81 (2008): 39-51, doi:10.3354/dao01931.en_US
dc.description.abstractGiardia intestinalis is a microbial eukaryotic parasite that causes diarrheal disease in humans and other vertebrates worldwide. The negative effect on quality of life and economics caused by G. intestinalis may be increased by its potential status as a zoonosis, or a disease that can be transmitted from animals to humans. The zoonotic potential of G. intestinalis has been implied for over 2 decades, with human-infecting genotypes (belonging to the 2 major subgroups, Assemblages A and B) occurring in wildlife and domesticated animals. There are recent reports of G. intestinalis in shellfish, seals, sea lions and whales, suggesting that marine animals are also potential reservoirs of human disease. However, the prevalence, genetic diversity and effect of G. intestinalis in marine environments and the role that marine animals play in transmission of this parasite to humans are relatively unexplored. Here, we provide the first thorough molecular characterization of G. intestinalis in marine vertebrates. Using a multi-locus sequencing approach, we identify human-infecting G. intestinalis haplotypes of both Assemblages A and B in the fecal material of dolphins, porpoises, seals, herring gulls Larus argentatus, common eiders Somateria mollissima and a thresher shark Alopias vulpinus. Our results indicate that G. intestinalis is prevalent in marine ecosystems, and a wide range of marine hosts capable of harboring zoonotic forms of this parasite exist. The presence of G. intestinalis in marine ecosystems raises concerns about how this disease might be transmitted among different host species.en_US
dc.description.sponsorshipThis paper is a result of research funded under the following awards: NOAA Coastal Ocean Program award no. NA05NOS4781247, the NOAA Prescott Program award no. NA06NMF4390130, the COHH award no. NIEHS P50ES012742, and the National Science Foundation OCE award no. 0430724 given to Woods Hole Oceanographic Institution, Woods Hole, Massachusetts and the National Institutes of Health award no. AI0580C4 ‘Molecular Evolution of Eukaryotes,’ given to the Marine Biological Laboratory, Woods Hole.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.publisherInter-Researchen_US
dc.relation.urihttp://dx.doi.org/10.3354/dao01931
dc.subjectGiardia intestinalisen_US
dc.subjectZoonosisen_US
dc.subjectMarine birdsen_US
dc.subjectMarine mammalsen_US
dc.subjectThresher sharken_US
dc.titleMolecular characterization of Giardia intestinalis haplotypes in marine animals : variation and zoonotic potentialen_US
dc.typeArticleen_US
dc.identifier.doi10.3354/dao01931


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