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Molecular characterization of Giardia intestinalis haplotypes in marine animals : variation and zoonotic potential

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dc.contributor.author Lasek-Nesselquist, Erica
dc.contributor.author Bogomolni, Andrea L.
dc.contributor.author Gast, Rebecca J.
dc.contributor.author Mark Welch, David B.
dc.contributor.author Ellis, Julie C.
dc.contributor.author Sogin, Mitchell L.
dc.contributor.author Moore, Michael J.
dc.date.accessioned 2011-04-08T18:08:10Z
dc.date.available 2011-04-08T18:08:10Z
dc.date.issued 2008-08-19
dc.identifier.citation Diseases of Aquatic Organisms 81 (2008): 39-51 en_US
dc.identifier.uri http://hdl.handle.net/1912/4448
dc.description Author Posting. © Inter-Research, 2008. This article is posted here by permission of Inter-Research for personal use, not for redistribution. The definitive version was published in Diseases of Aquatic Organisms 81 (2008): 39-51, doi:10.3354/dao01931. en_US
dc.description.abstract Giardia intestinalis is a microbial eukaryotic parasite that causes diarrheal disease in humans and other vertebrates worldwide. The negative effect on quality of life and economics caused by G. intestinalis may be increased by its potential status as a zoonosis, or a disease that can be transmitted from animals to humans. The zoonotic potential of G. intestinalis has been implied for over 2 decades, with human-infecting genotypes (belonging to the 2 major subgroups, Assemblages A and B) occurring in wildlife and domesticated animals. There are recent reports of G. intestinalis in shellfish, seals, sea lions and whales, suggesting that marine animals are also potential reservoirs of human disease. However, the prevalence, genetic diversity and effect of G. intestinalis in marine environments and the role that marine animals play in transmission of this parasite to humans are relatively unexplored. Here, we provide the first thorough molecular characterization of G. intestinalis in marine vertebrates. Using a multi-locus sequencing approach, we identify human-infecting G. intestinalis haplotypes of both Assemblages A and B in the fecal material of dolphins, porpoises, seals, herring gulls Larus argentatus, common eiders Somateria mollissima and a thresher shark Alopias vulpinus. Our results indicate that G. intestinalis is prevalent in marine ecosystems, and a wide range of marine hosts capable of harboring zoonotic forms of this parasite exist. The presence of G. intestinalis in marine ecosystems raises concerns about how this disease might be transmitted among different host species. en_US
dc.description.sponsorship This paper is a result of research funded under the following awards: NOAA Coastal Ocean Program award no. NA05NOS4781247, the NOAA Prescott Program award no. NA06NMF4390130, the COHH award no. NIEHS P50ES012742, and the National Science Foundation OCE award no. 0430724 given to Woods Hole Oceanographic Institution, Woods Hole, Massachusetts and the National Institutes of Health award no. AI0580C4 ‘Molecular Evolution of Eukaryotes,’ given to the Marine Biological Laboratory, Woods Hole. en_US
dc.format.mimetype application/pdf
dc.language.iso en en_US
dc.publisher Inter-Research en_US
dc.relation.uri http://dx.doi.org/10.3354/dao01931
dc.subject Giardia intestinalis en_US
dc.subject Zoonosis en_US
dc.subject Marine birds en_US
dc.subject Marine mammals en_US
dc.subject Thresher shark en_US
dc.title Molecular characterization of Giardia intestinalis haplotypes in marine animals : variation and zoonotic potential en_US
dc.type Article en_US
dc.identifier.doi 10.3354/dao01931


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