The role of sulfhydryl and disulfide groups of membrane proteins in electrical conduction and chemical transmission
del Castillo, Jose
MetadataShow full item record
KeywordSulfhydryl reagents; Electrical conduction; Chemical transmission; Voltage-dependent channels; Postnynaptic receptors
The chemical reactions of sulfhydryl and disulfide groups in proteins are discussed and the use of reagents specific for these groups as a tool in electrophysiology is reviewed. The drastic and specific changes seen when these group-specific reagents are used demonstrate the critical role of sulfhydryl and disulfide groups in electrical excitability, synaptic transmission and, particularly, postsynaptic receptor function. Sulfhydryl groups have been shown to be involved in the slow inactivation process of the voltage-dependent sodium channel, in the activation of voltage-dependent calcium channels and in sodium channel conductance. Sulfhydryl and disulfide groups have been shown to Intervene in the function of the acetylcholine receptor at the vertebrate neuromuscular junction and in invertebrate glutaminergic recepton. The release of neurotransmitter from the presynaptic termInals of these neuromuscular junctions Is also sensitive to sulfhydryl and disulfide group modification. Although in most instances the site of action of the reagents has not been resolved, their use has produced a clearer picture of receptor and channel structure-function relationships.
Author Posting. © University of Puerto Rico Medical Sciences Campus, 1984. This article is posted here by permission of University of Puerto Rico Medical Sciences Campus for personal use, not for redistribution. The definitive version was published in Puerto Rico Health Sciences Journal 3 (1984): 125-139.
Suggested CitationPuerto Rico Health Sciences Journal 3 (1984): 125-139
Showing items related by title, author, creator and subject.
Edmunds, Peter J.; Tsounis, Georgios (Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: firstname.lastname@example.org, 2020-02-20)Light data (transmission) from surveys conducted in Great Lameshur Bay, St. John, US Virgin Islands in 2017. These data were used in Edmunds et al. (2019) in Figure 2. For a complete list of measurements, refer to the ...
Hemichannel composition and electrical synaptic transmission : molecular diversity and its implications for electrical rectification Palacios-Prado, Nicolas; Huetteroth, Wolf; Pereda, Alberto E. (Frontiers Media, 2014-10-15)Unapposed hemichannels (HCs) formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological and pathological conditions. On the other hand, less is known ...
Faber, Donald S.; Pereda, Alberto E. (Frontiers Media, 2018-11-21)Electrical signaling is a cardinal feature of the nervous system and endows it with the capability of quickly reacting to changes in the environment. Although synaptic communication between nerve cells is perceived to be ...