The role of sulfhydryl and disulfide groups of membrane proteins in electrical conduction and chemical transmission
del Castillo, Jose
MetadataShow full item record
KeywordSulfhydryl reagents; Electrical conduction; Chemical transmission; Voltage-dependent channels; Postnynaptic receptors
The chemical reactions of sulfhydryl and disulfide groups in proteins are discussed and the use of reagents specific for these groups as a tool in electrophysiology is reviewed. The drastic and specific changes seen when these group-specific reagents are used demonstrate the critical role of sulfhydryl and disulfide groups in electrical excitability, synaptic transmission and, particularly, postsynaptic receptor function. Sulfhydryl groups have been shown to be involved in the slow inactivation process of the voltage-dependent sodium channel, in the activation of voltage-dependent calcium channels and in sodium channel conductance. Sulfhydryl and disulfide groups have been shown to Intervene in the function of the acetylcholine receptor at the vertebrate neuromuscular junction and in invertebrate glutaminergic recepton. The release of neurotransmitter from the presynaptic termInals of these neuromuscular junctions Is also sensitive to sulfhydryl and disulfide group modification. Although in most instances the site of action of the reagents has not been resolved, their use has produced a clearer picture of receptor and channel structure-function relationships.
Author Posting. © University of Puerto Rico Medical Sciences Campus, 1984. This article is posted here by permission of University of Puerto Rico Medical Sciences Campus for personal use, not for redistribution. The definitive version was published in Puerto Rico Health Sciences Journal 3 (1984): 125-139.
Showing items related by title, author, creator and subject.
Hemichannel composition and electrical synaptic transmission : molecular diversity and its implications for electrical rectification Palacios-Prado, Nicolas; Huetteroth, Wolf; Pereda, Alberto E. (Frontiers Media, 2014-10-15)Unapposed hemichannels (HCs) formed by hexamers of gap junction proteins are now known to be involved in various cellular processes under both physiological and pathological conditions. On the other hand, less is known ...
Prediction of silicate melt viscosity from electrical conductivity : a model and its geophysical implications Pommier, Anne; Evans, Rob L.; Key, Kerry; Tyburczy, James A.; Mackwell, Stephen; Elsenbeck, James R. (John Wiley & Sons, 2013-06-12)Our knowledge of magma dynamics would be improved if geophysical data could be used to infer rheological constraints in melt-bearing zones. Geophysical images of the Earth's interior provide frozen snapshots of a dynamical ...
Water in cratonic lithosphere : calibrating laboratory-determined models of electrical conductivity of mantle minerals using geophysical and petrological observations Jones, Alan G.; Fullea, Javier; Evans, Rob L.; Muller, Mark R. (American Geophysical Union, 2012-06-14)Measurements of electrical conductivity of “slightly damp” mantle minerals from different laboratories are inconsistent, requiring geophysicists to make choices between them when interpreting their electrical observations. ...