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dc.contributor.authorAlliegro, Mark C.  Concept link
dc.date.accessioned2011-02-16T19:21:44Z
dc.date.available2012-02-03T09:31:39Z
dc.date.issued2011-01-03
dc.identifier.urihttps://hdl.handle.net/1912/4340
dc.descriptionAuthor Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Chromosome Research 19 (2011): 367-376, doi:10.1007/s10577-011-9186-7.en_US
dc.description.abstractThe presence of nucleic acids in centrosomes and the spindle have been proposed, observed, and reported since the 1950s. Why did the subject remain, perhaps even until today, such a controversial issue? The explanation is manifold, and includes legitimate concern over contamination from other cellular compartments in biochemical preparations. With a typically high background of cytoplasmic ribosomes, even microscopic images of stained intact cells could be difficult to interpret. Also, evidence for RNA and DNA in centrosomes accumulated for approximately 40 years but was interspersed with contradictory studies, primarily regarding the presence of DNA (reviewed in Johnson and Rosenbaum, 1991; Marshall and Rosenbaum, 2000). Perhaps less tangible but still a likely cause for lingering controversy is that the presence of nucleic acids in the spindle or centrosomes will require us to look differently at these structures from a functional, and more to the point, evolutionary standpoint.en_US
dc.description.sponsorshipThis work was supported by grants from the NIH (GM088503) and NSF (MCB0843092) to MCA.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1007/s10577-011-9186-7
dc.subjectCentrosomeen_US
dc.subjectSpindleen_US
dc.subjectCentrosomal RNAen_US
dc.subjectNucleolinusen_US
dc.subjectCentrioleen_US
dc.subjectCell divisionen_US
dc.titleThe centrosome and spindle as a ribonucleoprotein complexen_US
dc.typePreprinten_US


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