• Login
    About WHOAS
    View Item 
    •   WHOAS Home
    • Marine Biological Laboratory
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    • View Item
    •   WHOAS Home
    • Marine Biological Laboratory
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WHOASCommunities & CollectionsBy Issue DateAuthorsTitlesKeywordsThis CollectionBy Issue DateAuthorsTitlesKeywords

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    The centrosome and spindle as a ribonucleoprotein complex

    Thumbnail
    View/Open
    Alliegro revised manuscript.pdf (2.411Mb)
    Date
    2011-01-03
    Author
    Alliegro, Mark C.  Concept link
    Metadata
    Show full item record
    Citable URI
    https://hdl.handle.net/1912/4340
    As published
    https://doi.org/10.1007/s10577-011-9186-7
    Keyword
     Centrosome; Spindle; Centrosomal RNA; Nucleolinus; Centriole; Cell division 
    Abstract
    The presence of nucleic acids in centrosomes and the spindle have been proposed, observed, and reported since the 1950s. Why did the subject remain, perhaps even until today, such a controversial issue? The explanation is manifold, and includes legitimate concern over contamination from other cellular compartments in biochemical preparations. With a typically high background of cytoplasmic ribosomes, even microscopic images of stained intact cells could be difficult to interpret. Also, evidence for RNA and DNA in centrosomes accumulated for approximately 40 years but was interspersed with contradictory studies, primarily regarding the presence of DNA (reviewed in Johnson and Rosenbaum, 1991; Marshall and Rosenbaum, 2000). Perhaps less tangible but still a likely cause for lingering controversy is that the presence of nucleic acids in the spindle or centrosomes will require us to look differently at these structures from a functional, and more to the point, evolutionary standpoint.
    Description
    Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Chromosome Research 19 (2011): 367-376, doi:10.1007/s10577-011-9186-7.
    Collections
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Preprint: Alliegro, Mark C., "The centrosome and spindle as a ribonucleoprotein complex", 2011-01-03, https://doi.org/10.1007/s10577-011-9186-7, https://hdl.handle.net/1912/4340
     

    Related items

    Showing items related by title, author, creator and subject.

    • Thumbnail

      Composition and dynamics of the nucleolinus, a link between the nucleolus and cell division apparatus in surf clam (Spisula) oocytes 

      Alliegro, Mark C.; Hartson, Steven; Alliegro, Mary Anne (2011-12-26)
      The nucleolinus is a little-known cellular structure, discovered over 150 years ago (1) and thought by some investigators in the late 19th to mid-20th century to function in the formation of the centrosomes or spindle. ...
    • Thumbnail

      The karyomastigont as an evolutionary seme 

      Chapman, Michael; Alliegro, Mark C. (University of Chicago Press, 2012-12)
      The problem of eukaryogenesis—the evolutionary mechanism whereby eukaryotic cells evolved from prokaryotes—remains one of the great unsolved mysteries of cell biology, possibly due to the reductionist tendency of most ...
    • Thumbnail

      Extra centrosomes and/or chromosomes prolong mitosis in human cells 

      Yang, Zhenye; Loncarek, Jadranka; Khodjakov, Alexey; Rieder, Conly L. (2008-04-04)
      Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We find that doubling the chromosome number adds ~10 minutes to a ...
    All Items in WHOAS are protected by original copyright, with all rights reserved, unless otherwise indicated. WHOAS also supports the use of the Creative Commons licenses for original content.
    A service of the MBLWHOI Library | About WHOAS
    Contact Us | Send Feedback | Privacy Policy
    Core Trust Logo