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    Harmonic analysis of the cone flicker ERG of rabbit

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    Qianetal_EER-2010.pdf (861.9Kb)
    Date
    2010-10-23
    Author
    Qian, Haohua  Concept link
    Alexander, Kenneth R.  Concept link
    Ripps, Harris  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/4301
    As published
    https://doi.org/10.1016/j.exer.2010.10.005
    DOI
    10.1016/j.exer.2010.10.005
    Keyword
     Electroretinogram; Flicker ERG; Rabbit; Cone pathway; Pharmacology; Sinusoidal stimuli; Frequency response 
    Abstract
    Harmonic analysis was used to characterize the rabbit flicker ERG elicited by sinusoidally modulated full-field stimuli under light-adapted conditions. The frequency-response function for fundamental amplitude, derived from Fourier analysis of the ERG waveforms, exhibited two limbs, with an amplitude minimum at approximately 30 Hz, and a high-frequency region peaking at around 45 Hz and extending to more than 100 Hz at higher adapting levels. At low frequencies (<20 Hz), the fundamental response amplitude was independent of mean luminance (Weber law behavior), whereas the response amplitude at high stimulus frequencies varied nonlinearly with mean luminance. At low frequencies, intravitreal administration of L-AP4, which blocks ON-pathway activity, reduced the fundamental response amplitude and produced a phase shift. On the other hand, PDA, which reduces OFF-pathway activity, had a minimal effect on both the response amplitude and phase at low frequencies. At high frequencies, L-AP4 increased the fundamental response amplitude at low mean luminances, whereas PDA had only a small effect on amplitude and phase. Both pharmacologic agents removed the minimum in the amplitude-frequency function as well as the abrupt change in phase at stimulus frequencies near 30 Hz. The results suggest that there is a nonlinear interaction between ON- and OFF-pathway activity over the entire stimulus frequency range examined in this study. These findings provide a basis for formulating protocols to evaluate the effect of pharmacologic agents and/or disease on the cone flicker ERG of rabbit.
    Description
    This paper is not subject to U.S. copyright. The definitive version was published in Experimental Eye Research 91 (2010): 811-817, doi:10.1016/j.exer.2010.10.005.
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    Suggested Citation
    Experimental Eye Research 91 (2010): 811-817
     
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