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dc.contributor.authorGladyshev, Eugene A.  Concept link
dc.contributor.authorArkhipova, Irina R.  Concept link
dc.date.accessioned2010-10-20T15:50:05Z
dc.date.available2011-04-30T08:24:44Z
dc.date.issued2010-01
dc.identifier.urihttps://hdl.handle.net/1912/3967
dc.descriptionAuthor Posting. © The Author(s), 2010. This is the author's version of the work. It is posted here by permission of Oxford University Press for personal use, not for redistribution. The definitive version was published in Journal of Heredity 101 (2010): S85-S93, doi:10.1093/jhered/esq008.en_US
dc.description.abstractBdelloid rotifers are microscopic invertebrate animals best known for their ancient asexuality and the ability to survive desiccation at any life stage. Both factors are expected to have a profound influence on their genome structure. Recent molecular studies demonstrated that, while the gene-rich regions of bdelloid genomes are organized as co-linear pairs of closely related sequences and depleted in repetitive DNA, subtelomeric regions harbor diverse transposable elements and horizontally acquired genes of foreign origin. While asexuality is expected to result in depletion of deleterious transposons, only desiccation appears to have the power to produce all of the uncovered genomic peculiarities. Repair of desiccation-induced DNA damage would require the presence of a homologous template, maintaining co-linear pairs in gene-rich regions, and selecting against insertion of repetitive DNA which might cause chromosomal rearrangements. Desiccation may also induce a transient state of competence in recovering animals, allowing them to acquire environmental DNA. Even if bdelloids engage in rare or obscure forms of sexual reproduction, all these features could still be present. The relative contribution of asexuality and desiccation to genome organization may be clarified by analyzing whole-genome sequences and comparing foreign gene and transposon content in species which lost the ability to survive desiccation.en_US
dc.description.sponsorshipThis work was supported by the National Science Foundation (grant MCB-0821956 to I.A.).en_US
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.relation.urihttps://doi.org/10.1093/jhered/esq008
dc.subjectAncient asexualsen_US
dc.subjectAnhydrobiosisen_US
dc.subjectTransposable elementsen_US
dc.subjectMobile DNAen_US
dc.subjectHorizontal gene transferen_US
dc.titleGenome structure of bdelloid rotifers : shaped by asexuality or desiccation?en_US
dc.typePreprinten_US


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