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dc.contributor.authorReitzel, Adam M.  Concept link
dc.contributor.authorTarrant, Ann M.  Concept link
dc.date.accessioned2010-09-30T17:38:20Z
dc.date.available2011-05-21T08:24:53Z
dc.date.issued2010-05-11
dc.identifier.urihttps://hdl.handle.net/1912/3925
dc.descriptionAuthor Posting. © The Authors, 2010. This is the author's version of the work. It is posted here by permission of Oxford University Press for personal use, not for redistribution. The definitive version was published in Molecular Biology and Evolution 27 (2010): 2211-2215, doi:10.1093/molbev/msq129.en_US
dc.description.abstractConserved interactions among proteins or other molecules can provide strong evidence for coevolution across their evolutionary history. Diverse phylogenetic methods have been applied to identify potential coevolutionary relationships. In most cases, these methods minimally require comparisons of orthologous sequences and appropriate controls to separate effects of selection from the overall evolutionary relationships. In vertebrates, androgen receptor (AR) and cytochrome p450 aromatase (CYP19) share an affinity for androgenic steroids, which serve as receptor ligands and enzyme substrates. In a recent study, Tiwary and Li (2009) reported that AR and CYP19 displayed a signature of ancient and conserved interactions throughout all of the Eumetazoa (i.e., cnidarians, protostomes, and deuterostomes). Because these findings conflicted with a number of previous studies, we reanalyzed the data set used by Tiwary and Li. First, our analyses demonstrate that the invertebrate genes used in the previous analysis are not orthologous sequences, but instead represent a diverse set of nuclear receptors and cytochrome p450 enzymes with no confirmed or hypothesized relationships with androgens. Second, we show that (1) their analytical approach, which measures correlations in evolutionary distances between proteins, potentially led to spurious significant relationships due simply to conserved domains and (2) control comparisons provide positive evidence for a strong influence of evolutionary history. We discuss how corrections to this method and analysis of key taxa (e.g., duplications in the teleost fish and suiform lineages) can inform investigations of the coevolutionary relationships between androgen receptor and aromatase.en_US
dc.description.sponsorshipAMR was supported by the Postdoctoral Scholar Program at the Woods Hole Oceanographic Institution, with funding provided by The Beacon Institute for Rivers and Estuaries, and AMT was supported by WHOI Assistant Scientist Endowed Support.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.relation.urihttps://doi.org/10.1093/molbev/msq129
dc.subjectAndrogen receptoren_US
dc.subjectAromataseen_US
dc.subjectCorrelated evolutionen_US
dc.subjectCytochrome p450en_US
dc.subjectNuclear receptoren_US
dc.titleCorrelated evolution of androgen receptor and aromatase revisiteden_US
dc.typePreprinten_US


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