Show simple item record

dc.contributor.authorAluru, Neelakanteswar  Concept link
dc.contributor.authorLeatherland, John F.  Concept link
dc.contributor.authorVijayan, Mathilakath M.  Concept link
dc.date.accessioned2010-06-16T13:16:59Z
dc.date.available2010-06-16T13:16:59Z
dc.date.issued2010-05-20
dc.identifier.citationPLoS ONE 5 (2010): e10741en_US
dc.identifier.urihttps://hdl.handle.net/1912/3644
dc.description© The Authors, 2010. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS ONE 5 (2010): e10741, doi:10.1371/journal.pone.0010741.en_US
dc.description.abstractBisphenol A (BPA), used in the manufacture of plastics, is ubiquitously distributed in the aquatic environment. However, the effect of maternal transfer of these xenobiotics on embryonic development and growth is poorly understood in fish. We tested the hypothesis that BPA in eggs, mimicking maternal transfer, impact development, growth and stress performance in juveniles of rainbow trout (Oncorhynchus mykiss). Trout oocytes were exposed to 0, 30 and 100 µg.mL−1 BPA for 3 h in ovarian fluid, followed by fertilization. The embryos were maintained in clean water and sampled temporally over 156-days post-fertilization (dpf), and juveniles were sampled at 400-dpf. The egg BPA levels declined steadily after exposure and were undetectable after 21- dpf. Oocyte exposure to BPA led to a delay in hatching and yolk absorption and a consistently lower body mass over 152-dpf. The growth impairment, especially in the high BPA group, correlated with higher growth hormone (GH) content and lower GH receptors gene expression. Also, mRNA abundances of insulin-like growth factors (IGF-1 and IGF-2) and their receptors were suppressed in the BPA treated groups. The juvenile fish grown from the BPA-enriched eggs had lower body mass and showed perturbations in plasma cortisol and glucose response to an acute stressor. BPA accumulation in eggs, prior to fertilization, leads to hatching delays, growth suppression and altered stress response in juvenile trout. The somatotropic axis appears to be a key target for BPA impact during early embryogenesis, leading to long term growth and stress performance defects in fish.en_US
dc.description.sponsorshipThis work was supported by funds from the Natural Science and Engineering Research Council (NSERC) of Canada Discovery grant and the Ontario Ministry of Agriculture and Food.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.urihttps://doi.org/10.1371/journal.pone.0010741
dc.rightsAttribution 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/*
dc.titleBisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trouten_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0010741


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 3.0 Unported
Except where otherwise noted, this item's license is described as Attribution 3.0 Unported