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dc.contributor.authorWachowiak, Matt  Concept link
dc.contributor.authorCohen, Lawrence B.  Concept link
dc.date.accessioned2005-12-30T19:50:31Z
dc.date.available2005-12-30T19:50:31Z
dc.date.issued2001-04-13
dc.identifier.urihttps://hdl.handle.net/1912/363
dc.descriptionAuthor Posting. © The Author(s), 2001. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Neuron 32 (2001): 723-735, doi:10.1016/S0896-6273(01)00506-2.
dc.description.abstractTo visualize odorant representations by receptor neuron input to the mouse olfactory bulb, we loaded receptor neurons with calcium-sensitive dye and imaged odorant-evoked responses from their axon terminals. Fluorescence increases reflected activation of receptor neuron populations converging onto individual glomeruli. We report several findings. First, five glomeruli were identifiable across animals based on their location and odorant responsiveness; all five showed complex response specificities. Second, maps of input were chemotopically organized at near-threshold concentrations but, at moderate concentrations, involved many widely distributed glomeruli. Third, the dynamic range of input to a glomerulus was greater than that reported for individual receptor neurons. Finally, odorant activation slopes could differ across glomeruli, and for different odorants activating the same glomerulus. These results imply a high degree of complexity in odorant representations at the level of olfactory bulb input.en
dc.description.sponsorshipThis work was supported by NIH NS08437-DC05259 and DC00378-03.en
dc.format.extent750404 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.relation.urihttps://doi.org/10.1016/S0896-6273(01)00506-2
dc.titleRepresentation of odorants by receptor neuron input to the mouse olfactory bulben
dc.typePreprinten


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