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dc.contributor.authorIzumi, Michi  Concept link
dc.contributor.authorSweeney, Alison M.  Concept link
dc.contributor.authorDeMartini, Daniel  Concept link
dc.contributor.authorWeaver, James C.  Concept link
dc.contributor.authorPowers, Meghan L.  Concept link
dc.contributor.authorTao, Andrea  Concept link
dc.contributor.authorSilvas, Tania V.  Concept link
dc.contributor.authorKramer, Ryan M.  Concept link
dc.contributor.authorCrookes-Goodson, Wendy J.  Concept link
dc.contributor.authorMathger, Lydia M.  Concept link
dc.contributor.authorNaik, Rajesh R.  Concept link
dc.contributor.authorHanlon, Roger T.  Concept link
dc.contributor.authorMorse, Daniel E.  Concept link
dc.date.accessioned2010-02-08T14:54:03Z
dc.date.available2010-02-08T14:54:03Z
dc.date.issued2009-07-18
dc.identifier.urihttps://hdl.handle.net/1912/3158
dc.descriptionAuthor Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of The Royal Society for personal use, not for redistribution. The definitive version was published in Journal of The Royal Society Interface 6 (2010): 549-560, doi:10.1098/rsif.2009.0299.en_US
dc.description.abstractMany cephalopods exhibit remarkable dermal iridescence, a component of their complex, dynamic camouflage and communication. In the species Euprymna scolopes, the light-organ iridescence is static and is due to reflectin protein-based platelets assembled into lamellar thin-film reflectors called iridosomes, contained within iridescent cells called iridocytes. Squid in the family Loliginidae appear to be unique in that the dermis possesses a dynamic iridescent component, with reflective, colored structures that are assembled and disassembled under the control of the muscarinic cholinergic system and the associated neurotransmitter acetylcholine (Mathger et al. 2004). Here we present the sequences and characterization of three new members of the reflectin family associated with the dynamically changeable iridescence in Loligo and not found in static Euprymna iridophores. In addition, we show that application of genistein, a protein tyrosine kinase inhibitor, suppresses acetylcholine- and calcium-induced iridescence in Loligo. We further demonstrate that two of these novel reflectins are extensively phosphorylated in concert with the activation of iridescence by exogenous acetylcholine. This phosphorylation and the correlated iridescence can be blocked with genistein. Our results suggest that tyrosine phosphorylation of reflectin proteins is involved in the regulation of dynamic iridescence in Loligo.en_US
dc.description.sponsorshipWe gratefully acknowledge support from Anteon contract F33615-03-D-5408 to the Marine Biological Laboratory, Woods Hole, MA and grant # W911NF-06-1-0285 from the Army Research Office to D.E.M.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.relation.urihttps://doi.org/10.1098/rsif.2009.0299
dc.titleChanges in reflectin protein phosphorylation are associated with dynamic iridescence in squiden_US
dc.typePreprinten_US


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