Halogenated 1'-methyl-1,2'-bipyrroles (MBPs) in the northwestern Atlantic
Pangallo, Kristin C.
MetadataShow full item record
Halogenated 1’-methyl-1,2’-bipyrroles (MBPs) are a distinctive class of marine organic compounds. They are naturally produced, they have a unique carbon structure, they are highly halogenated, and they bioaccumulate in upper trophic levels. MBPs share many characteristics with persistent organic pollutants (POPs), and may prove to be useful natural analogues for these anthropogenic compounds. Further, their unique structure suggests that their biosynthetic organism(s) may have new genes to add to current knowledge of biosynthetic chemistry. The objectives of this dissertation were to further clarify the environmental distribution of MBPs, to examine whether MBPs biomagnify, and to investigate possible origins of these compounds through their stable nitrogen isotopic signatures. Results from these investigations have shown that over 40 highly brominated MBP congeners are present in marine mammals, fish, and squid from the Northwestern Atlantic Ocean. The most abundant MBPs do appear to biomagnify through the food web to reach the concentrations observed in marine mammals. This additional evidence affords greater confidence in the use of MBPs as natural analogues for POPs. However, differences in the environmental chemistry of MBPs and anthropogenic compounds are also evident, and may be due to these compounds’ different origins, or to the capacity of degradative enzymes to act upon them. Finally, compound-specific nitrogen isotope analyses on MBPs isolated from dolphin blubber show that these compounds are dramatically enriched in 15N relative to other biosynthetic organic compounds. This enrichment is likely a signal imparted during biosynthesis, and may assist in elucidating the organism(s) and mechanism(s) responsible for the biosynthesis of MBPs.
Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the Massachusetts Institute of Technology and the Woods Hole Oceanographic Institution September 2009
Showing items related by title, author, creator and subject.
Waldbauer, Jacob R. (Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 2010-02)Biological activity has shaped the surface of the earth in numerous ways, but life’s most pervasive and persistent global impact has been the secular oxidation of the surface environment. Through primary production – the ...
Temporal variability and vertical structure in larval abundance : the potential roles of biological and physical processes Garland, Elizabeth D. (Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 2000-02)Recruitment variability in benthic invertebrate populations results from variability in planktonic larval supply and from processes occurring during and after larval settlement onto the seafloor. The focus of this thesis ...
Physiological and behavioral diagnostics of nitrogen limitation for the toxic dinoflagellate Alexandrium fundyense Poulton, Nicole J. (Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 2000-09)One challenge in phytoplankton ecology is to measure species-specific physiological responses to changes in environmental conditions. Of particular importance in this regard are harmful algal bloom (RAB) species such as ...