• Login
    About WHOAS
    View Item 
    •   WHOAS Home
    • Woods Hole Oceanographic Institution
    • Biology
    • View Item
    •   WHOAS Home
    • Woods Hole Oceanographic Institution
    • Biology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of WHOASCommunities & CollectionsBy Issue DateAuthorsTitlesKeywordsThis CollectionBy Issue DateAuthorsTitlesKeywords

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Environmental sensing and response genes in cnidaria : the chemical defensome in the sea anemone Nematostella vectensis

    Thumbnail
    View/Open
    CBTO479_revised_WHOAS.pdf (579.4Kb)
    Date
    2008-10
    Author
    Goldstone, Jared V.  Concept link
    Metadata
    Show full item record
    Citable URI
    https://hdl.handle.net/1912/3049
    As published
    https://doi.org/10.1007/s10565-008-9107-5
    Keyword
     Cytochrome P450; Glutathione transferase; ABC transporter; Aromatic hydrocarbon; Nuclear receptor; Metal; Superoxide dismutase; Oxidative stress 
    Abstract
    The starlet sea anemone Nematostella vectensis has been recently established as a new model system for the study of the evolution of developmental processes, as cnidaria occupy a key evolutionary position at the base of the bilateria. Cnidaria play important roles in estuarine and reef communities, but are exposed to many environmental stressors. Here I describe the genetic components of a ‘chemical defensome’ in the genome of N. vectensis, and review cnidarian molecular toxicology. Gene families that defend against chemical stressors and the transcription factors that regulate these genes have been termed a ‘chemical defensome,’ and include the cytochromes P450 and other oxidases, various conjugating enyzymes, the ATP-dependent efflux transporters, oxidative detoxification proteins, as well as various transcription factors. These genes account for about 1% (266/27200) of the predicted genes in the sea anemone genome, similar to the proportion observed in tunicates and humans, but lower than that observed in sea urchins. While there are comparable numbers of stress-response genes, the stress sensor genes appear to be reduced in N. vectensis relative to many model protostomes and deuterostomes. Cnidarian toxicology is understudied, especially given the important ecological roles of many cnidarian species. New genomic resources should stimulate the study of chemical stress sensing and response mechanisms in cnidaria, and allow us to further illuminate the evolution of chemical defense gene networks.
    Description
    Author Posting. © The Author(s), 2008. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Cell Biology and Toxicology 24 (2008): 483-502, doi:10.1007/s10565-008-9107-5.
    Collections
    • Biology
    Suggested Citation
    Preprint: Goldstone, Jared V., "Environmental sensing and response genes in cnidaria : the chemical defensome in the sea anemone Nematostella vectensis", 2008-10, https://doi.org/10.1007/s10565-008-9107-5, https://hdl.handle.net/1912/3049
     
    All Items in WHOAS are protected by original copyright, with all rights reserved, unless otherwise indicated. WHOAS also supports the use of the Creative Commons licenses for original content.
    A service of the MBLWHOI Library | About WHOAS
    Contact Us | Send Feedback | Privacy Policy
    Core Trust Logo