Marine Biological Laboratory: Recent submissions
Now showing items 1-20 of 8841
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Sox17 and ß-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network
(eLife Sciences Publications, 2020-09-07)Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive ... -
The hierarchical assembly of septins revealed by high-speed AFM
(Nature Research, 2020-10-08)Septins are GTP-binding proteins involved in diverse cellular processes including division and membrane remodeling. Septins form linear, palindromic heteromeric complexes that can assemble in filaments and higher-order ... -
A pushing mechanism for microtubule aster positioning in a large cell type
(Cell Press, 2020-10-06)After fertilization, microtubule (MT) sperm asters undergo long-range migration to accurately position pronuclei. Due to the large sizes of zygotes, the forces driving aster migration are considered to be from pulling on ... -
Role of C4 carbon fixation in Ulva prolifera, the macroalga responsible for the world's largest green tides
(Nature Research, 2020-09-07)Most marine algae preferentially assimilate CO2 via the Calvin-Benson Cycle (C3) and catalyze HCO3− dehydration via carbonic anhydrase (CA) as a CO2-compensatory mechanism, but certain species utilize the Hatch-Slack Cycle ... -
Editorial: role of protein palmitoylation in synaptic plasticity and neuronal differentiation
(Frontiers Media, 2020-07-09)Protein palmitoylation, the reversible addition of palmitate to proteins, is a dynamic post-translational modification. Both membrane (e.g., channels, transporters, and receptors) and cytoplasmic proteins (e.g., cell ... -
CRISPR/Cas9 mediated mutation of the mtnr1a melatonin receptor gene causes rod photoreceptor degeneration in developing Xenopus tropicalis
(Nature Research, 2020-08-13)Nighttime surges in melatonin levels activate melatonin receptors, which synchronize cellular activities with the natural light/dark cycle. Melatonin receptors are expressed in several cell types in the retina, including ... -
Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos
(Nature Research, 2020-09-04)CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F0 animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes ... -
Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking
(American Society for Cell Biology, 2020-06-29)The spatial structure and physical properties of the cytosol are not well understood. Measurements of the material state of the cytosol are challenging due to its spatial and temporal heterogeneity. Recent development of ... -
Buzzards Bay Water Quality Data from the Buzzards Bay Coalition’s Baywatchers Program 1992-2018 August 2020 version
(Woods Hole Oceanographic Institution, 2020-08-28)The Buzzards Bay Coalition’s Baywatchers Monitoring Program collected summertime water quality information at more than 150 stations around Buzzards Bay, Massachusetts from 1992 to 2018. Baywatchers monitoring data document ... -
Conserved metabolite regulation of stress granule assembly via AdoMet
(Rockefeller University Press, 2020-07-01)Stress granules (SGs) are evolutionarily conserved condensates of ribonucleoproteins that assemble in response to metabolic stresses. Because aberrant SG formation is associated with amyotrophic lateral sclerosis (ALS), ... -
Cover crops and chicken grazing in a winter fallow field improve soil carbon and nitrogen contents and decrease methane emissions
(Nature Research, 2020-07-28)Using symbiotic farming methods [cover crops and chicken grazing (+ C)] in a winter fallow field, we found that the soil organic matter and total nitrogen of the + C treatment were 5.2% and 26.6% higher, respectively, than ... -
"Whole-body imaging of neural and muscle activity during behavior in hydra vulgaris: effect of osmolarity on contraction bursts"
(Society for Neuroscience, 2020-07-22)The neural code relates the activity of the nervous system to the activity of the muscles to the generation of behavior. To decipher it, it would be ideal to comprehensively measure the activity of the entire nervous system ... -
Microbial diversity drives carbon use efficiency in a model soil
(Nature Research, 2020-07-23)Empirical evidence for the response of soil carbon cycling to the combined effects of warming, drought and diversity loss is scarce. Microbial carbon use efficiency (CUE) plays a central role in regulating the flow of ... -
Ink release and swimming behavior in the oceanic Ctenophore Eurhamphaea vexilligera
(University of Chicago Press, 2020-06-08)Of the more than 150 ctenophore species, the oceanic ctenophore Eurhamphaea vexilligera is notable for its bright orange-yellow ink, secreted from numerous small vesicles that line its substomodeal comb rows. To date, in ... -
Shared up-regulation and contrasting down-regulation of gene expression distinguish desiccation-tolerant from intolerant green algae
(National Academy of Sciences, 2020-07-21)Among green plants, desiccation tolerance is common in seeds and spores but rare in leaves and other vegetative green tissues. Over the last two decades, genes have been identified whose expression is induced by desiccation ... -
α-Synuclein-112 impairs synaptic vesicle recycling consistent with its enhanced membrane binding properties
(Frontiers Media, 2020-05-29)Synucleinopathies are neurological disorders associated with α-synuclein overexpression and aggregation. While it is well-established that overexpression of wild type α-synuclein (α-syn-140) leads to cellular toxicity and ... -
Far-field unlabeled super-resolution imaging with superoscillatory illumination
(AIP Publishing, 2020-06-19)Unlabeled super-resolution is the next grand challenge in imaging. Stimulated emission depletion and single-molecule microscopies have revolutionized the life sciences but are still limited by the need for reporters (labels) ... -
Long-term imaging of the photosensitive, reef-building coral Acropora muricata using light-sheet illumination
(Nature Research, 2020-06-25)Coral reefs are in alarming decline due to climate emergency, pollution and other man-made disturbances. The numerous ecosystem services derived from coral reefs are underpinned by the growth and physical complexity of ... -
A demographic and evolutionary analysis of maternal effect senescence
(National Academy of Sciences, 2020-06-29)Maternal effect senescence—a decline in offspring survival or fertility with maternal age—has been demonstrated in many taxa, including humans. Despite decades of phenotypic studies, questions remain about how maternal ...
