Now showing items 1-20 of 8909

    • Swimming kinematics and performance of spinal transected lampreys with different levels of axon regeneration 

      Fies, Jacob; Gemmell, Brad J.; Fogerson, Stephanie M.; Morgan, Jennifer R.; Tytell, Eric D.; Colin, Sean P. (The Company of Biologists, 2021-11-05)
      Axon regeneration is critical for restoring neural function after spinal cord injury. This has prompted a series of studies on the neural and functional recovery of lampreys after spinal cord transection. Despite this, ...
    • Warming effects on arctic tundra biogeochemistry are limited but habitat-dependent: a meta-analysis 

      Pold, Grace; Baillargeon, Natalie; Lepe, Adan; Rastetter, Edward B.; Sistla, Seeta A. (Ecological Society of America, 2021-10-12)
      Arctic tundra consists of diverse habitats that differ in dominant vegetation, soil moisture regimes, and relative importance of organic vs. inorganic nutrient cycling. The Arctic is also the most rapidly warming global ...
    • Deep learning is widely applicable to phenotyping embryonic development and disease 

      Naert, Thomas; Çiçek, Özgün; Ogar, Paulina; Bürgi, Max; Shaidani, Nikko-Ideen; Kaminski, Michael M.; Xu, Yuxiao; Grand, Kelli; Vujanovic, Marko; Prata, Daniel; Hildebrandt, Friedhelm; Brox, Thomas; Ronneberger, Olaf; Voigt, Fabian F.; Helmchen, Fritjof; Loffing, Johannes; Horb, Marko E.; Rankin Willsey, Helen; Lienkamp, Soeren S. (The Company of Biologists, 2021-11-05)
      Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how ...
    • Imaging of dynamic actin remodeling reveals distinct behaviors of head and trunk mesoderm in gastrulating Xenopus laevis 

      Komatsu, Valerie; Doddihal, Viraj; Chang, Chenbei (Caltech Library, 2021-10-14)
      Gastrulation involves coordinated movements of cells, facilitating mesoderm and endoderm internalization and proper patterning of tissues across the germ layers. In Xenopus laevis, head mesoderm migrates collectively along ...
    • Mathematical modeling accurately predicts the dynamics and scaling of nuclear growth in discrete cytoplasmic volumes 

      Leech, Vivienne; Hazel, James W.; Gatlin, Jesse C.; Lindsay, Alan E.; Manhart, Angelika (Elsevier, 2021-10-22)
      Scaling of nuclear size with cell size has been observed in many species and cell types. In this work we formulate a modeling framework based on the limiting component hypothesis. We derive a family of spatio-temporal ...
    • Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome 

      Govind, Anitha P.; Jeyifous, Okunola; Russell, Theron A.; Yi, Zola; Weigel, Aubrey V.; Ramaprasad, Abhijit; Newell, Luke; Ramos, William; Valbuena, Fernando M.; Casler, Jason C.; Yan, Jing-Zhi; Glick, Benjamin S.; Swanson, Geoffrey T.; Lippincott-Schwartz, Jennifer; Green, William N. (eLife Sciences Publications, 2021-09-21)
      Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity, and related diseases, but their mechanistic basis and significance are unclear. Here, we observed that ...
    • Model responses to CO(2) and warming are underestimated without explicit representation of Arctic small-mammal grazing 

      Rastetter, Edward B.; Griffin, Kevin L.; Rowe, Rebecca J.; Gough, Laura; McLaren, Jennie; Boelman, Natalie (Ecological Society of America, 2021-10-17)
      We use a simple model of coupled carbon and nitrogen cycles in terrestrial ecosystems to examine how “explicitly representing grazers” vs. “having grazer effects implicitly aggregated in with other biogeochemical processes ...
    • Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling 

      Woods, Benjamin L.; Cannon, Kevin S.; Vogt, Ellysa J. D.; Crutchley, John M.; Gladfelter, Amy S. (American Society for Cell Biology, 2021-09-09)
      The curvature of the membrane defines cell shape. Septins are GTP-binding proteins that assemble into heteromeric complexes and polymerize into filaments at areas of micron-scale membrane curvature. An amphipathic helix ...
    • Frontotemporal lobar dementia mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism 

      Combs, Benjamin; Christensen, Kyle R.; Richards, Collin; Kneynsberg, Andrew; Mueller, Rebecca L.; Morris, Sarah L.; Morfini, Gerardo A.; Brady, Scott T.; Kanaan, Nicholas M. (Society for Neuroscience, 2021-10-04)
      Pathologic tau modifications are characteristic of Alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. Inherited mutations in tau cause early onset frontotemporal lobar dementias ...
    • Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish 

      Brun, Nadja R.; Panlilio, Jennifer M.; Zhang, Kun; Zhao, Yanbin; Ivashkin, Evgeny; Stegeman, John J.; Goldstone, Jared V. (Nature Research, 2021-09-24)
      The most abundant polychlorinated biphenyl (PCB) congeners found in the environment and in humans are neurotoxic. This is of particular concern for early life stages because the exposure of the more vulnerable developing ...
    • The Nereid on the rise: Platynereis as a model system 

      Ozpolat, B. Duygu; Randel, Nadine; Williams, Elizabeth A.; Bezares-Calderón, Luis Alberto; Andreatta, Gabriele; Balavoine, Guillaume; Bertucci, Paola Y.; Ferrier, David E. K.; Gambi, Maria Cristina; Gazave, Eve; Handberg-Thorsager, Mette; Hardege, Jörg; Hird, Cameron; Hsieh, Yu-Wen; Hui, Jerome; Mutemi, Kevin Nzumbi; Schneider, Stephan Q.; Simakov, Oleg; Vergara, Hernando M.; Vervoort, Michel; Jékely, Gáspár; Tessmar-Raible, Kristin; Raible, Florian; Arendt, Detlev (BMC, 2021-09-27)
      The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195–269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a ...
    • Explaining regeneration: cells and limbs as complex living systems, learning from history 

      MacCord, Kate; Maienschein, Jane (Frontiers Media, 2021-08-31)
      Regeneration has been investigated since Aristotle, giving rise to many ways of explaining what this process is and how it works. Current research focuses on gene expression and cell signaling of regeneration within ...
    • Real-time polarization microscopy of fibrillar collagen in histopathology 

      Keikhosravi, Adib; Shribak, Michael; Conklin, Matthew W.; Liu, Yuming; Li, Bin; Loeffler, Agnes; Levenson, Richard; Eliceiri, Kevin (Nature Research, 2021-09-24)
      Over the past two decades, fibrillar collagen reorganization parameters such as the amount of collagen deposition, fiber angle and alignment have been widely explored in numerous studies. These parameters are now widely ...
    • Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses 

      Li, Shuo; Raychaudhuri, Sumana; Lee, Stephen Alexander; Brockmann, Marisa M.; Wang, Jing; Kusick, Grant; Prater, Christine; Syed, Sarah; Falahati, Hanieh; Ramos, Raul; Bartol, Tomas M.; Hosy, Eric; Watanabe, Shigeki (Nature Research, 2021-01-29)
      Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous ...
    • Emerging wetlands from river diversions can sustain high denitrification rates in a Coastal Delta 

      Upreti, Kiran; Rivera-Monroy, Victor H.; Maiti, Kanchan; Giblin, Anne E.; Geaghan, James P. (American Geophysical Union, 2021-03-31)
      It is assumed that to treat excess NO3− high soil organic matter content (%OM) is required to maintain high denitrification rates in natural or restored wetlands. However, this excess also represents a risk by increasing ...
    • A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo 

      Hawk, Josh D.; Wisdom, Elias M.; Sengupta, Titas; Kashlan, Zane D.; Colón-Ramos, Daniel (Nature Research, 2021-08-09)
      Chemogenetic and optogenetic tools have transformed the field of neuroscience by facilitating the examination and manipulation of existing circuits. Yet, the field lacks tools that enable rational rewiring of circuits via ...
    • Understanding the effects of climate change via disturbance on pristine arctic lakes-multitrophic level response and recovery to a 12-yr, low-level fertilization experiment 

      Budy, Phaedra; Pennock, Casey A.; Giblin, Anne E.; Luecke, Chris; White, Daniel L.; Kling, George W. (Association for the Sciences of Limnology and Oceanography, 2021-08-02)
      Effects of climate change-driven disturbance on lake ecosystems can be subtle; indirect effects include increased nutrient loading that could impact ecosystem function. We designed a low-level fertilization experiment to ...
    • Open ocean particle flux variability from surface to seafloor 

      Cael, B. Barry; Bisson, Kelsey; Conte, Maureen H.; Duret, Manon T.; Follett, Christopher L.; Henson, Stephanie A.; Honda, Makio C.; Iversen, Morten H.; Karl, David M.; Lampitt, Richard S.; Mouw, Colleen B.; Muller-Karger, Frank E.; Pebody, Corinne; Smith, Kenneth L., Jr.; Talmy, David (American Geophysical Union, 2021-04-18)
      The sinking of carbon fixed via net primary production (NPP) into the ocean interior is an important part of marine biogeochemical cycles. NPP measurements follow a log-normal probability distribution, meaning NPP variations ...
    • A cross-institutional analysis of the effects of broadening trainee professional development on research productivity 

      Brandt, Patrick D.; Sturzenegger Varvayanis, Susi; Baas, Tracey; Bolgioni, Amanda F.; Alder, Janet; Petrie, Kimberly A.; Dominguez, Isabel; Brown, Abigail M.; Stayart, C. Abigail; Singh, Harinder; Van Wart, Audra; Chow, Christine S.; Mathur, Ambika; Schreiber, Barbara M.; Fruman, David A.; Bowden, Brent; Wiesen, Christopher A.; Golightly, Yvonne M.; Holmquist, Chris E.; Arneman, Daniel; Hall, Joshua D.; Hyman, Linda E.; Gould, Kathleen L.; Chalkley, Roger; Brennwald, Patrick J.; Layton, Rebekah L. (Public Library of Science, 2021-07-15)
      PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit organizations. Hence, best practices for training the future ...
    • Teamwork in the viscous oceanic microscale 

      Kanso, Eva A.; Lopes, Rubens M.; Strickler, J. Rudi; Dabiri, John O.; Costello, John H. (National Academy of Sciences, 2021-07-16)
      Nutrient acquisition is crucial for oceanic microbes, and competitive solutions to solve this challenge have evolved among a range of unicellular protists. However, solitary solutions are not the only approach found in ...