Now showing items 1-20 of 8887

    • NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions 

      Münzer, Patrick; Negro, Roberto; Fukui, Shoichi; di Meglio, Lucas; Aymonnier, Karen; Chu, Long; Cherpokova, Deya; Gutch, Sarah; Sorvillo, Nicoletta; Shi, Lai; Magupalli, Venkat Giri; Weber, Alexander N. R.; Scharf, Rüdiger E.; Waterman, Clare M.; Wu, Hao; Wagner, Denisa D. (Frontiers Media, 2021-03-28)
      Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated ...
    • Degradation of biological macromolecules supports uncultured microbial populations in Guaymas Basin hydrothermal sediments 

      Pérez Castro, Sherlynette; Borton, Mikayla A.; Regan, Kathleen M.; Hrabe de Angelis, Isabella; Wrighton, Kelly C.; Teske, Andreas P.; Strous, Marc; Ruff, S. Emil (Springer Nature, 2021-06-10)
      Hydrothermal sediments contain large numbers of uncultured heterotrophic microbial lineages. Here, we amended Guaymas Basin sediments with proteins, polysaccharides, nucleic acids or lipids under different redox conditions ...
    • Post-stroke epileptogenesis is associated with altered intrinsic properties of hippocampal pyramidal neurons leading to increased theta resonance 

      Vera, Jorge; Lippmann, Kristina (Elsevier, 2021-06-10)
      Brain insults like stroke, trauma or infections often lead to blood-brain barrier-dysfunction (BBBd) frequently resulting into epileptogenesis. Affected patients suffer from seizures and cognitive comorbidities that are ...
    • Fungal community response to long-term soil warming with potential implications for soil carbon dynamics 

      Pec, Gregory J.; van Diepen, Linda T. A.; Knorr, Melissa; Grandy, A. Stuart; Melillo, Jerry M.; DeAngelis, Kristen M.; Blanchard, Jeffrey L.; Frey, Serita D. (Ecological Society of America, 2021-05-11)
      The direction and magnitude of climate warming effects on ecosystem processes such as carbon cycling remain uncertain. Soil fungi are central to these processes due to their roles as decomposers of soil organic matter, as ...
    • Time lags: insights from the U.S. Long Term Ecological Research Network 

      Rastetter, Edward B.; Ohman, Mark D.; Elliott, Katherine J.; Rehage, Jennifer S.; Rivera-Monroy, Victor H.; Boucek, Ross E.; Castaneda-Moya, Edward; Danielson, Tess M.; Gough, Laura; Groffman, Peter M.; Jackson, C. Rhett; Ford Miniat, Chelcy (Ecological Society of America, 2021-05-17)
      Ecosystems across the United States are changing in complex ways that are difficult to predict. Coordinated long-term research and analysis are required to assess how these changes will affect a diverse array of ecosystem ...
    • Oxygen supply capacity breathes new life into critical oxygen partial pressure (Pcrit) 

      Seibel, Brad A.; Andres, Alyssa; Birk, Matthew A.; Burns, Alexandra L.; Shaw, C. Tracy; Timpe, Alexander W.; Welsh, Christina J. (The Company of Biologists, 2021-04-30)
      The critical oxygen partial pressure (Pcrit), typically defined as the PO2 below which an animal's metabolic rate (MR) is unsustainable, is widely interpreted as a measure of hypoxia tolerance. Here, Pcrit is defined as ...
    • Global ocean sediment composition and burial flux in the deep sea 

      Hayes, Christopher T.; Costa, Kassandra M.; Anderson, Robert F.; Calvo, Eva; Chase, Zanna; Demina, Ludmila L.; Dutay, Jean-Claude; German, Christopher R.; Heimbürger, Lars-Eric; Jaccard, Samuel L.; Jacobel, Allison W.; Kohfeld, Karen E.; Kravchishina, Marina; Lippold, Jörg; Mekik, Figen; Missiaen, Lise; Pavia, Frank; Paytan, Adina; Pedrosa-Pamies, Rut; Petrova, Mariia V.; Rahman, Shaily; Robinson, Laura F.; Roy-Barman, Matthieu; Sanchez-Vidal, Anna; Shiller, Alan M.; Tagliabue, Alessandro; Tessin, Allyson C.; van Hulten, Marco; Zhang, Jing (American Geophysical Union, 2021-03-21)
      Quantitative knowledge about the burial of sedimentary components at the seafloor has wide-ranging implications in ocean science, from global climate to continental weathering. The use of 230Th-normalized fluxes reduces ...
    • Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning 

      Tani, Tomomi; Koike-Tani, Maki; Tran, Mai Thi; Shribak, Michael; Levic, Snezana (Nature Research, 2021-04-07)
      The basilar membrane (BM) of the mammalian cochlea constitutes a spiraling acellular ribbon that is intimately attached to the organ of Corti. Its graded stiffness, increasing from apex to the base of the cochlea provides ...
    • Spatial variation of microtubule depolymerization in large asters 

      Ishihara, Keisuke; Decker, Franziska; Caldas, Paulo; Pelletier, James F.; Loose, Martin; Brugués, Jan; Mitchison, Timothy J. (American Society for Cell Biology, 2021-04-19)
      Microtubule plus-end depolymerization rate is a potentially important target of physiological regulation, but it has been challenging to measure, so its role in spatial organization is poorly understood. Here we apply a ...
    • Buzzards Bay Water Quality Data from the Buzzards Bay Coalition’s Baywatchers Program 1992-2020 

      Jakuba, Rachel W.; Williams, Tony; Neill, Christopher; Costa, Joseph E.; McHorney, Richard; Scott, Lindsay; Howes, Brian L.; Ducklow, Hugh W.; Erickson, Matthew; Rasmussen, Mark (Woods Hole Oceanographic Institution, 2021-07-09)
      The Buzzards Bay Coalition’s Baywatchers Monitoring Program collected summertime water quality information at more than 150 stations around Buzzards Bay, Massachusetts from 1992 to 2020. Baywatchers monitoring data document ...
    • Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw 

      Hirschberger, Christine; Sleight, Victoria A.; Criswell, Katharine E.; Clark, Stephen J.; Gillis, J. Andrew (Oxford University Press, 2021-04-27)
      The origin of the jaw is a long-standing problem in vertebrate evolutionary biology. Classical hypotheses of serial homology propose that the upper and lower jaw evolved through modifications of dorsal and ventral gill ...
    • Representativeness of eddy-covariance flux footprints for areas surrounding AmeriFlux sites 

      Chu, Housen; Luo, Xiangzhong; Ouyang, Zutao; Chan, W. Stephen; Dengel, Sigrid; Biraud, Sebastien; Torn, Margaret S.; Metzger, Stefan; Kumar, Jitendra; Arain, M. Altaf; Arkebauer, Tim J.; Baldocchi, Dennis D.; Bernacchi, Carl; Billesbach, Dave; Black, T. Andrew; Blanken, Peter D.; Bohrer, Gil; Bracho, Rosvel; Brown, Shannon; Brunsell, Nathaniel A.; Chen, Jiquan; Chen, Xingyuan; Clark, Kenneth; Desai, Ankur R.; Duman, Tomer; Durden, David J.; Fares, Silvano; Forbrich, Inke; Gamon, John; Gough, Christopher M.; Griffis, Timothy; Helbig, Manuel; Hollinger, David; Humphreys, Elyn; Ikawa, Hiroki; Iwata, Hiroki; Ju, Yang; Knowles, John F.; Knox, Sara H.; Kobayashi, Hideki; Kolb, Thomas; Law, Beverly; Lee, Xuhui; Litvak, Marcy; Liu, Heping; Munger, J. William; Noormets, Asko; Novick, Kim; Oberbauer, Steven F.; Oechel, Walter; Oikawa, Patty; Papuga, Shirley A.; Pendall, Elise; Prajapati, Prajaya; Prueger, John; Quinton, William L.; Richardson, Andrew D.; Russell, Eric S.; Scott, Russell L.; Starr, Gregory; Staebler, Ralf; Stoy, Paul C.; Stuart-Haëntjens, Ellen; Sonnentag, Oliver; Sullivan, Ryan C.; Suyker, Andy; Ueyama, Masahito; Vargas, Rodrigo; Wood, Jeffrey D.; Zona, Donatella (Elsevier, 2021-02-14)
      Large datasets of greenhouse gas and energy surface-atmosphere fluxes measured with the eddy-covariance technique (e.g., FLUXNET2015, AmeriFlux BASE) are widely used to benchmark models and remote-sensing products. This ...
    • Atmospheric and oceanographic forcing impact particle flux composition and carbon sequestration in the eastern Mediterranean Sea: a three-year time-series study in the deep Ierapetra Basin 

      Pedrosa-Pamies, Rut; Parinos, Constantine; Sanchez-Vidal, Anna; Calafat, Antoni; Canals, Miquel; Velaoras, Dimitris; Mihalopoulos, Nikolaos; Kanakidou, Maria; Lampadariou, Nikolaos; Gogou, Alexandra (Frontiers Media, 2021-02-25)
      Sinking particles are a critical conduit for the export of organic material from surface waters to the deep ocean. Despite their importance in oceanic carbon cycling, little is known about the biotic composition and seasonal ...
    • Tau: a signaling hub protein 

      Mueller, Rebecca L.; Combs, Benjamin; Alhadidy, Mohammed M.; Brady, Scott T.; Morfini, Gerardo A.; Kanaan, Nicholas M. (Frontiers Media, 2021-03-19)
      Over four decades ago, in vitro experiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties ...
    • Effects of excess brain-derived human alpha-synuclein on synaptic vesicle trafficking 

      Román-Vendrell, Cristina; Medeiros, Audrey T.; Sanderson, John B.; Jiang, Haiyang; Bartels, Tim; Morgan, Jennifer R. (Frontiers Media, 2021-02-04)
      α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and ...
    • Neuromechanical wave resonance in jellyfish swimming 

      Hoover, Alexander P.; Xu, Nicole W.; Gemmell, Brad J.; Colin, Sean P.; Costello, John H.; Dabiri, John O.; Miller, Laura A. (National Academy of Sciences, 2021-03-16)
      For organisms to have robust locomotion, their neuromuscular organization must adapt to constantly changing environments. In jellyfish, swimming robustness emerges when marginal pacemakers fire action potentials throughout ...
    • HP1 proteins compact DNA into mechanically and positionally stable phase separated domains 

      Keenen, Madeline M.; Brown, David; Brennan, Lucy D.; Renger, Roman; Khoo, Harrison; Carlson, Christopher R.; Huang, Bo; Grill, Stephan W.; Narlikar, Geeta J.; Redding, Sy (eLife Sciences Publications, 2021-03-04)
      In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether ...
    • New species can broaden myelin research: suitability of little skate, Leucoraja erinacea 

      Möbius, Wiebke; Hümmert, Sophie; Ruhwedel, Torben; Kuzirian, Alan M.; Gould, Robert M. (MDPI, 2021-02-11)
      Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination ...
    • Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis 

      Torres, Joshua P.; Lin, Zhenjian; Watkins, Maren; Salcedo, Paula Flórez; Baskin, Robert P.; Elhabian, Shireen; Safavi-Hemami, Helena; Taylor, Dylan; Tun, Jortan; Concepcion, Gisela P.; Saguil, Noel; Yanagihara, Angel A.; Fang, Yixin; McArthur, Jeffrey R.; Tae, Han-Shen; Finol-Urdaneta, Rocio K.; Ozpolat, B. Duygu; Olivera, Baldomero M.; Schmidt, Eric W. (American Association for the Advancement of Science, 2021-03-12)
      Venomous animals hunt using bioactive peptides, but relatively little is known about venom small molecules and the resulting complex hunting behaviors. Here, we explored the specialized metabolites from the venom of the ...
    • Identifying and assessing effectiveness of alternative low-effort nitrogen footprint reductions in small research institutions 

      Messenger, Sarah; Lloret, Javier; Galloway, James; Giblin, Anne E. (IOP Publishing, 2021-02-25)
      Concern over the ecological damage of excess nitrogen has brought increased attention to the role of research institutions and universities in contributing to this problem. Institutions often utilize the concept of the ...