Now showing items 171-180 of 877
Review : Zinc’s functional significance in the vertebrate retina
(Molecular Vision, 2014-07-31)
This review covers a broad range of topics related to the actions of zinc on the cells of the vertebrate retina. Much of this review relies on studies in which zinc was applied exogenously, and therefore the results, albeit ...
The evolution of the four subunits of voltage-gated calcium channels : ancient roots, increasing complexity, and multiple losses
(Oxford University Press, 2014-08-21)
The alpha subunits of voltage-gated calcium channels (Cavs) are large transmembrane proteins responsible for crucial physiological processes in excitable cells. They are assisted by three auxiliary subunits that can modulate ...
Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity
Mitochondria manufacture and release metabolites and manage calcium during neuronal activity and synaptic transmission, but whether long term alterations in mitochondrial function contribute to neuronal plasticity that ...
The microbiome in pediatric cystic fibrosis patients : the role of shared environment suggests a window of intervention
(BioMed Central, 2014-04-28)
Cystic fibrosis (CF) is caused by mutations in the CFTR gene that predispose the airway to infection. Chronic infection by pathogens such as Pseudomonas aeruginosa leads to inflammation that gradually degrades lung function, ...
Application of DMSP/OLS nighttime light images : a meta-analysis and a systematic literature review
(MDPI AG, 2014-07-25)
Since the release of the digital archives of Defense Meteorological Satellite Program Operational Line Scanner (DMSP/OLS) nighttime light data in 1992, a variety of datasets based on this database have been produced and ...
Repurposing human PDE4 inhibitors for neglected tropical diseases : design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors
A medicinal chemistry exploration of the human phosphodiesterase 4 (hPDE4) inhibitor cilomilast (1) was undertaken in order to identify inhibitors of phosphodiesterase B1 of Trypanosoma brucei (TbrPDEB1). T. brucei is the ...
MIxS-BE : a MIxS extension defining a minimum information standard for sequence data from the built environment
(Nature Publishing Group, 2013-10-24)
The need for metadata standards for microbe sampling in the built environment.
Draft genome sequence of marine alphaproteobacterial strain HIMB11, the first cultivated representative of a unique lineage within the Roseobacter clade possessing an unusually small genome
(Genomic Standards Consortium, 2014)
Strain HIMB11 is a planktonic marine bacterium isolated from coastal seawater in Kaneohe Bay, Oahu, Hawaii belonging to the ubiquitous and versatile Roseobacter clade of the alphaproteobacterial family Rhodobacteraceae. ...
Evaluating remotely sensed phenological metrics in a dynamic ecosystem model
(MDPI AG, 2014-05-26)
Vegetation phenology plays an important role in regulating processes of terrestrial ecosystems. Dynamic ecosystem models (DEMs) require representation of phenology to simulate the exchange of matter and energy between the ...
Employing BAC-reporter constructs in the sea anemone Nematostella vectensis
Changes in the expression and function of genes drive evolutionary change. Comparing how genes are regulated in different species is therefore becoming an important part of evo-devo studies. A key tool for investigating ...