Now showing items 1-2 of 2

  • Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase 

    Morfini, Gerardo A.; Bosco, Daryl A.; Brown, Hannah; Gatto, Rodolfo; Kaminska, Agnieszka; Song, Yuyu; Molla, Linda; Baker, Lisa; Marangoni, M. Natalia; Berth, Sarah; Tavassoli, Ehsan; Bagnato, Carolina; Tiwari, Ashutosh; Hayward, Lawrence J.; Pigino, Gustavo F.; Watterson, D. Martin; Huang, Chun-Fang; Banker, Gary; Brown, Robert H.; Brady, Scott T. (Public Library of Sceince, 2013-06-12)
    Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of ...
  • Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin 

    Morfini, Gerardo A.; You, Yi-Mei; Pollema, Sarah L.; Kaminska, Agnieszka; Liu, Katherine; Yoshioka, Katsuji; Bjorkblom, Benny; Coffey, Eleanor T.; Bagnato, Carolina; Han, David; Huang, Chun-Fang; Banker, Gary; Pigino, Gustavo F.; Brady, Scott T. (2009-04-28)
    Selected vulnerability of neurons in Huntington’s disease (HD) suggests alterations in a cellular process particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal ...