Now showing items 1-3 of 3

    • The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity 

      LaPointe, Nichole E.; Morfini, Gerardo A.; Pigino, Gustavo F.; Gaisina, Irina N.; Kozikowski, Alan P.; Binder, Lester I.; Brady, Scott T. (2008-04)
      The neuropathology of Alzheimer’s disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule-associated protein tau, but the relationship between tau polymerization and neurotoxicity ...
    • HIV glycoprotein Gp120 impairs fast axonal transport by activating Tak1 signaling pathways 

      Berth, Sarah; Mesnard-Hoaglin, Nichole; Wang, Bin; Kim, Hajwa; Song, Yuyu; Sapar, Maria; Morfini, Gerardo A.; Brady, Scott T. (Sage, 2016-11-01)
      Sensory neuropathies are the most common neurological complication of HIV. Of these, distal sensory polyneuropathy (DSP) is directly caused by HIV infection and characterized by length-dependent axonal degeneration of ...
    • Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin 

      Morfini, Gerardo A.; You, Yi-Mei; Pollema, Sarah L.; Kaminska, Agnieszka; Liu, Katherine; Yoshioka, Katsuji; Bjorkblom, Benny; Coffey, Eleanor T.; Bagnato, Carolina; Han, David; Huang, Chun-Fang; Banker, Gary; Pigino, Gustavo F.; Brady, Scott T. (2009-04-28)
      Selected vulnerability of neurons in Huntington’s disease (HD) suggests alterations in a cellular process particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal ...