Low-dose arsenic compromises the immune response to influenza A infection in vivo
Kozul, Courtney D.
Ely, Kenneth H.
Enelow, Richard I.
Hamilton, Joshua W.
MetadataShow full item record
Arsenic exposure is a significant worldwide environmental health concern. We recently reported that 5-week exposure to environmentally relevant levels (10 and 100 ppb) of As in drinking water significantly altered components of the innate immune response in mouse lung, which we hypothesize is an important contributor to the increased risk of lung disease in exposed human populations. We investigated the effects of As exposure on respiratory influenza A (H1N1) virus infection, a common and potentially fatal disease. In this study, we exposed C57BL/6J mice to 100 ppb As in drinking water for 5 weeks, followed by intranasal inoculation with a sublethal dose of influenza A/PuertoRico/8/34 (H1N1) virus. Multiple end points were assessed postinfection. Arsenic was associated with a number of significant changes in response to influenza, including an increase in morbidity and higher pulmonary influenza virus titers on day 7 postinfection. We also found many alterations in the immune response relative to As-unexposed controls, including a decrease in the number of dendritic cells in the mediastinal lymph nodes early in the course of infection. Our data indicate that chronic As exposure significantly compromises the immune response to infection. Alterations in response to repeated lung infection may also contribute to other chronic illnesses, such as bronchiectasis, which is elevated by As exposure in epidemiology studies.
This paper is not subject to U.S. copyright. The definitive version was published in Environmental Health Perspectives 117 (2009): 1441–1447, doi:10.1289/ehp.0900911.
Showing items related by title, author, creator and subject.
Kozul-Horvath, Courtney D.; Zandbergen, Fokko; Jackson, Brian P.; Enelow, Richard I.; Hamilton, Joshua W. (Public Library of Science, 2012-05-31)Arsenic (As) exposure is a significant worldwide environmental health concern. Chronic exposure via contaminated drinking water has been associated with an increased incidence of a number of diseases, including reproductive ...
Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung Kozul, Courtney D.; Hampton, Thomas H.; Davey, Jennifer C.; Gosse, Julie A.; Nomikos, Athena P.; Eisenhauer, Phillip L.; Weiss, Daniel J.; Thorpe, Jessica E.; Ihnat, Michael A.; Hamilton, Joshua W. (National Institute of Environmental Health Sciences, 2009-03-04)Chronic exposure to drinking water arsenic is a significant worldwide environmental health concern. Exposure to As is associated with an increased risk of lung disease, which may make it a unique toxicant, because lung ...