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dc.contributor.authorRabbitt, Richard D.  Concept link
dc.contributor.authorClifford, Sarah  Concept link
dc.contributor.authorBreneman, Kathryn D.  Concept link
dc.contributor.authorFarrell, Brenda  Concept link
dc.contributor.authorBrownell, William E.  Concept link
dc.date.accessioned2009-09-14T17:50:02Z
dc.date.available2009-09-14T17:50:02Z
dc.date.issued2009-07-24
dc.identifier.citationPLoS Computational Biology 5 (2009): e1000444en_US
dc.identifier.urihttps://hdl.handle.net/1912/2990
dc.description© 2009 Rabbitt et al. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS Computational Biology 5 (2009): e1000444, doi:10.1371/journal.pcbi.1000444.en_US
dc.description.abstractCochlear outer hair cells (OHCs) are fast biological motors that serve to enhance the vibration of the organ of Corti and increase the sensitivity of the inner ear to sound. Exactly how OHCs produce useful mechanical power at auditory frequencies, given their intrinsic biophysical properties, has been a subject of considerable debate. To address this we formulated a mathematical model of the OHC based on first principles and analyzed the power conversion efficiency in the frequency domain. The model includes a mixture-composite constitutive model of the active lateral wall and spatially distributed electro-mechanical fields. The analysis predicts that: 1) the peak power efficiency is likely to be tuned to a specific frequency, dependent upon OHC length, and this tuning may contribute to the place principle and frequency selectivity in the cochlea; 2) the OHC power output can be detuned and attenuated by increasing the basal conductance of the cell, a parameter likely controlled by the brain via the efferent system; and 3) power output efficiency is limited by mechanical properties of the load, thus suggesting that impedance of the organ of Corti may be matched regionally to the OHC. The high power efficiency, tuning, and efferent control of outer hair cells are the direct result of biophysical properties of the cells, thus providing the physical basis for the remarkable sensitivity and selectivity of hearing.en_US
dc.description.sponsorshipThis work was supported by NIDCD R01 DC04928 (Rabbitt), NIDCD R01 DC00384 (Brownell) and NASA Ames GSRA56000135 (Breneman).en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.urihttps://doi.org/10.1371/journal.pcbi.1000444
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titlePower efficiency of outer hair cell somatic electromotilityen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pcbi.1000444


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States