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    Distribution and phylogeny of Penelope-like elements in eukaryotes

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    Date
    2006-10
    Author
    Arkhipova, Irina R.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/2956
    As published
    https://doi.org/10.1080/10635150601077683
    DOI
    10.1080/10635150601077683
    Keyword
     Penelope-like elements; Retrotransposons; Reverse transcriptase; GIY-YIG endonuclease 
    Abstract
    Penelope-like elements (PLEs) are a relatively little studied class of eukaryotic retroelements, distinguished by the presence of the GIY-YIG endonuclease domain, the ability of some representatives to retain introns, and the similarity of PLE-encoded reverse transcriptases to telomerases. Although these retrotransposons are abundant in many animal genomes, the reverse transcriptase moiety can also be found in several protists, fungi, and plants, indicating its ancient origin. A comprehensive phylogenetic analysis of PLEs was conducted, based on extended sequence alignments and a considerably expanded data set. PLEs exhibit the pattern of evolution similar to that of non-LTR retrotransposons, which form deep-branching clades dating back to the Precambrian era. However, PLEs seem to have experienced a much higher degree of lineage losses than non-LTR retrotransposons. It is suggested that PLEs and non-LTR retrotransposons are included into a larger eTPRT (eukaryotic target-primed) group of retroelements, characterized by 5' truncation, variable target-site duplication, and the potential of the 3' end to participate in formation of non-autonomous derivatives.
    Description
    Author Posting. © Society of Systematic Biologists, 2006. This article is posted here by permission of Oxford University Press for personal use, not for redistribution. The definitive version was published in Systematic Biology 55 (2006): 875-885, doi:10.1080/10635150601077683.
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    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Systematic Biology 55 (2006): 875-885
     

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