Abstract:
The pole-to-pole distance of the metaphase spindle is reasonably constant in a given cell type; in the case of vertebrate female oocytes, this steady state length can be maintained for substantial lengths of time, during which time microtubules remain highly dynamic. While a number of molecular perturbations have been shown to influence spindle length, a global understanding of the factors that determine metaphase spindle length has not been achieved.
Description:
Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Elsevier B. V. for personal use, not for redistribution. The definitive version was published in Current Biology 15 (2005): 1979-1988, doi:10.1016/j.cub.2005.09.054.
