Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung
Date
2009-03-04Author
Kozul, Courtney D.
Concept link
Hampton, Thomas H.
Concept link
Davey, Jennifer C.
Concept link
Gosse, Julie A.
Concept link
Nomikos, Athena P.
Concept link
Eisenhauer, Phillip L.
Concept link
Weiss, Daniel J.
Concept link
Thorpe, Jessica E.
Concept link
Ihnat, Michael A.
Concept link
Hamilton, Joshua W.
Concept link
Metadata
Show full item recordCitable URI
https://hdl.handle.net/1912/2871As published
https://doi.org/10.1289/ehp.0800199DOI
10.1289/ehp.0800199Keyword
Arsenic; Inflammation; Innate immune system; Lung; MigrationAbstract
Chronic exposure to drinking water arsenic is a significant worldwide environmental health concern. Exposure to As is associated with an increased risk of lung disease, which may make it a unique toxicant, because lung toxicity is usually associated with inhalation rather than ingestion.
The goal of this study was to examine mRNA and protein expression changes in the lungs of mice exposed chronically to environmentally relevant concentrations of As in the food or drinking water, specifically examining the hypothesis that As may preferentially affect gene and protein expression related to immune function as part of its mechanism of toxicant action.
C57BL/6J mice fed a casein-based AIN-76A defined diet were exposed to 10 or 100 ppb As in drinking water or food for 5–6 weeks.
Whole genome transcriptome profiling of animal lungs revealed significant alterations in the expression of many genes with functions in cell adhesion and migration, channels, receptors, differentiation and proliferation, and, most strikingly, aspects of the innate immune response. Confirmation of mRNA and protein expression changes in key genes of this response revealed that genes for interleukin 1β, interleukin 1 receptor, a number of toll-like receptors, and several cytokines and cytokine receptors were significantly altered in the lungs of As-exposed mice.
These findings indicate that chronic low-dose As exposure at the current U.S. drinking-water standard can elicit effects on the regulation of innate immunity, which may contribute to altered disease risk, particularly in lung.
Description
This paper is not subject to U.S. copyright. The definitive version was published in Environmental Health Perspectives 117 (2009): 1108-1115, doi:10.1289/ehp.0800199.
Suggested Citation
Environmental Health Perspectives 117 (2009): 1108-1115Related items
Showing items related by title, author, creator and subject.
-
Low-dose arsenic compromises the immune response to influenza A infection in vivo
Kozul, Courtney D.; Ely, Kenneth H.; Enelow, Richard I.; Hamilton, Joshua W. (National Institute of Environmental Health Sciences, 2009-05-20)Arsenic exposure is a significant worldwide environmental health concern. We recently reported that 5-week exposure to environmentally relevant levels (10 and 100 ppb) of As in drinking water significantly altered components ... -
Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development
Kozul-Horvath, Courtney D.; Zandbergen, Fokko; Jackson, Brian P.; Enelow, Richard I.; Hamilton, Joshua W. (Public Library of Science, 2012-05-31)Arsenic (As) exposure is a significant worldwide environmental health concern. Chronic exposure via contaminated drinking water has been associated with an increased incidence of a number of diseases, including reproductive ... -
Sex-specific associations of infants’ gut microbiome with arsenic exposure in a US population
Hoen, Anne G.; Madan, Juliette C.; Li, Zhigang; Coker, Modupe O.; Lundgren, Sara N.; Morrison, Hilary G.; Palys, Thomas J.; Jackson, Brian P.; Sogin, Mitchell L.; Cottingham, Kathryn L.; Karagas, Margaret R. (Nature Publishing Group, 2018-08-22)Arsenic is a ubiquitous environmental toxicant with antimicrobial properties that can be found in food and drinking water. The influence of arsenic exposure on the composition of the human microbiome in US populations ...