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dc.contributor.authorBiller, Steven J.  Concept link
dc.contributor.authorLundeen, Rachel A.  Concept link
dc.contributor.authorHmelo, Laura R.  Concept link
dc.contributor.authorBecker, Kevin W.  Concept link
dc.contributor.authorArellano, Aldo A.  Concept link
dc.contributor.authorDooley, Keven  Concept link
dc.contributor.authorHeal, Katherine R.  Concept link
dc.contributor.authorCarlson, Laura Truxal  Concept link
dc.contributor.authorVan Mooy, Benjamin A. S.  Concept link
dc.contributor.authorIngalls, Anitra  Concept link
dc.contributor.authorChisholm, Sallie W.  Concept link
dc.date.accessioned2022-01-14T16:18:09Z
dc.date.available2022-01-14T16:18:09Z
dc.date.issued2021-11-12
dc.identifier.citationBiller, S. J., Lundeen, R. A., Hmelo, L. R., Becker, K. W., Arellano, A. A., Dooley, K., Heal, K. R., Carlson, L. T., Van Mooy, B. A. S., Ingalls, A. E., & Chisholm, S. W. (2022). Prochlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbes. Environmental Microbiology.en_US
dc.identifier.urihttps://hdl.handle.net/1912/27930
dc.description© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Biller, S. J., Lundeen, R. A., Hmelo, L. R., Becker, K. W., Arellano, A. A., Dooley, K., Heal, K. R., Carlson, L. T., Van Mooy, B. A. S., Ingalls, A. E., & Chisholm, S. W. Prochlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbes. Environmental Microbiology. (2022), https://doi.org/10.1111/1462-2920.15834.en_US
dc.description.abstractExtracellular vesicles are small (~50–200 nm diameter) membrane-bound structures released by cells from all domains of life. While vesicles are abundant in the oceans, their functions, both for cells themselves and the emergent ecosystem, remain a mystery. To better characterize these particles – a prerequisite for determining function – we analysed the lipid, protein, and metabolite content of vesicles produced by the marine cyanobacterium Prochlorococcus. We show that Prochlorococcus exports a diverse array of cellular compounds into the surrounding seawater enclosed within discrete vesicles. Vesicles produced by two different strains contain some materials in common, but also display numerous strain-specific differences, reflecting functional complexity within vesicle populations. The vesicles contain active enzymes, indicating that they can mediate extracellular biogeochemical reactions in the ocean. We further demonstrate that vesicles from Prochlorococcus and other bacteria associate with diverse microbes including the most abundant marine bacterium, Pelagibacter. Together, our data point toward hypotheses concerning the functional roles of vesicles in marine ecosystems including, but not limited to, possibly mediating energy and nutrient transfers, catalysing extracellular biochemical reactions, and mitigating toxicity of reactive oxygen species.en_US
dc.description.sponsorshipThis work was funded by grants from the National Science Foundation (OCE-1356460 to S.W.C.) and the Simons Foundation (SCOPE Award ID 329108 to B.A.S.V.M., A.E.I., S.W.C.; Life Sciences Project Award ID 337262, S.W.C.; Simons Award ID 385428 to A.E.I. and 598819 to K.R.H.). K.W.B was supported by the Postdoctoral Scholarship Programme at the Woods Hole Oceanographic Institution. R.A.L was partially supported by a postdoctoral fellowship from the Swiss National Science Foundation.en_US
dc.publisherSociety for Applied Microbiologyen_US
dc.relation.urihttps://doi.org/10.1111/1462-2920.15834
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleProchlorococcus extracellular vesicles: molecular composition and adsorption to diverse microbesen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/1462-2920.15834


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International