Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
Date
2021-03-18Metadata
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https://hdl.handle.net/1912/27584As published
https://doi.org/10.1038/s41598-021-85667-8DOI
10.1038/s41598-021-85667-8Abstract
Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes has been suggested. We applied polychromatic polarization microscopy to image their spatial organization. Our study provides evidence that IBI are caused by liquid paraffin-macromolecular crystals formed during paraffin-embedding procedures within cells and potentially reflect an active transcriptional status.
Description
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Vitkunaite, A., Laurinaviciene, A., Plancoulaine, B., Rasmusson, A., Levenson, R., Shribak, M., & Laurinavicius, A. Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy. Scientific Reports, 11(1), (2021): 6275, https://doi.org/10.1038/s41598-021-85667-8.
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Vitkunaite, A., Laurinaviciene, A., Plancoulaine, B., Rasmusson, A., Levenson, R., Shribak, M., & Laurinavicius, A. (2021). Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy. Scientific Reports, 11(1), 6275.The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Attribution 4.0 International