Show simple item record

dc.contributor.authorTani, Tomomi  Concept link
dc.contributor.authorKoike-Tani, Maki  Concept link
dc.contributor.authorTran, Mai Thi  Concept link
dc.contributor.authorShribak, Michael  Concept link
dc.contributor.authorLevic, Snezana  Concept link
dc.date.accessioned2021-07-14T20:04:16Z
dc.date.available2021-07-14T20:04:16Z
dc.date.issued2021-04-07
dc.identifier.citationTani, T., Koike-Tani, M., Tran, M. T., Shribak, M., & Levic, S. (2021). Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning. Scientific Reports, 11(1), 7581.en_US
dc.identifier.urihttps://hdl.handle.net/1912/27354
dc.description© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Tani, T., Koike-Tani, M., Tran, M. T., Shribak, M., & Levic, S. Postnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuning. Scientific Reports, 11(1), (2021): 7581, https://doi.org/10.1038/s41598-021-87150-w.en_US
dc.description.abstractThe basilar membrane (BM) of the mammalian cochlea constitutes a spiraling acellular ribbon that is intimately attached to the organ of Corti. Its graded stiffness, increasing from apex to the base of the cochlea provides the mechanical basis for sound frequency analysis. Despite its central role in auditory signal transduction, virtually nothing is known about the BM’s structural development. Using polarized light microscopy, the present study characterized the architectural transformations of freshly dissected BM at time points during postnatal development and maturation. The results indicate that the BM structural elements increase progressively in size, becoming radially aligned and more tightly packed with maturation and reach the adult structural signature by postnatal day 20 (P20). The findings provide insight into structural details and developmental changes of the mammalian BM, suggesting that BM is a dynamic structure that changes throughout the life of an animal.en_US
dc.description.sponsorshipThis work was supported by Medical Research Council grant MR/ N004299/1 (to SL), University of Sussex Research Innovation Funds (to SL), Brighton and Sussex Medical School research funds (to SL), National Institute of General Medical Sciences, NIH grant R01 GM101701 (to MS), NIH R01 GM100160 (to TT) and KAKENHI JP18K19962 (to TT).en_US
dc.publisherNature Researchen_US
dc.relation.urihttps://doi.org/10.1038/s41598-021-87150-w
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePostnatal structural development of mammalian basilar membrane provides anatomical basis for the maturation of tonotopic maps and frequency tuningen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41598-021-87150-w


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International