Editorial: role of protein palmitoylation in synaptic plasticity and neuronal differentiation
MetadataShow full item record
Keywordpalmitoylation and depalmitoylation; synaptic plasticity; axonal growth; lysosome; neurodegenerative disease; neuronal ceroid lipofuscinoses (NCL); Huntington disease
Protein palmitoylation, the reversible addition of palmitate to proteins, is a dynamic post-translational modification. Both membrane (e.g., channels, transporters, and receptors) and cytoplasmic proteins (e.g., cell adhesion, scaffolding, cytoskeletal, and signaling molecules) are substrates. In mammals, palmitoylation is mediated by 23-24 palmitoyl acyltransferases (PATs), also called ZDHHCs for their catalytic aspartate-histidine-histidine-cysteine (DHCC) domain. PATs are integral membrane proteins found in cellular membranes. In the palmitoylation cycle, palmitate is removed by the depalmitoylation enzymes, acyl palmitoyl transferases (APT1 and 2), and α/β Hydrolase domain-containing protein 17 (ABHD17A-C). These are cytoplasmic proteins that are targeted to membranes where they are substrates for PATs. The second class of depalmitoylating enzymes are palmitoyl thioesterases, PPT1 and 2, discovered through their association with infantile neuronal ceroid lipofuscinosis. These are secreted proteins found in the lumen of intracellular organelles, primarily lysosomes, where their function as depalmitoylating enzymes is unclear.
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Yoshii, A., & Green, W. N. Editorial: role of protein palmitoylation in synaptic plasticity and neuronal differentiation. Frontiers in Synaptic Neuroscience, 12(27), (2020), doi:10.3389/fnsyn.2020.00027.
Suggested CitationYoshii, A., & Green, W. N. (2020). Editorial: role of protein palmitoylation in synaptic plasticity and neuronal differentiation. Frontiers in Synaptic Neuroscience, 12(27).
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Sodium dynamics in pyramidal neuron dendritic spines : synaptically evoked entry predominantly through AMPA receptors and removal by diffusion Miyazaki, Kenichi; Ross, William N. (Society for Neuroscience, 2017-10-11)Dendritic spines are key elements underlying synaptic integration and cellular plasticity, but many features of these important structures are not known or are controversial. We examined these properties using newly developed ...
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity : a combined voltage- and calcium-imaging study Canepari, Marco; Djurisic, Maja; Zecevic, Dejan (2006-11-16)The non-linear and spatially inhomogeneous interactions of dendritic membrane potential signals that represent the first step in the induction of activity dependent long-term synaptic plasticity are not fully understood, ...
Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth Chen, Rongmin; Park, Han-A; Mnatsakanyan, Nelli; Niu, Yulong; Licznerski, Pawel; Wu, Jing; Miranda, Paige; Graham, Morven; Tang, Jack; Boon, Agnita J. W.; Cossu, Giovanni; Mandemakers, Wim; Bonifati, Vincenzo; Smith, Peter J. S.; Alavian, Kambiz N.; Jonas, Elizabeth A. (Springer Nature, 2019-06-13)Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F1FO ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mitochondrial ...