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dc.contributor.authorGerbich, Therese M.  Concept link
dc.contributor.authorMcLaughlin, Grace A.  Concept link
dc.contributor.authorCassidy, Katelyn  Concept link
dc.contributor.authorGerber, Scott  Concept link
dc.contributor.authorAdalsteinsson, David  Concept link
dc.contributor.authorGladfelter, Amy S.  Concept link
dc.date.accessioned2020-07-27T14:40:55Z
dc.date.available2020-07-27T14:40:55Z
dc.date.issued2020-07-06
dc.identifier.citationGerbich, T. M., McLaughlin, G. A., Cassidy, K., Gerber, S., Adalsteinsson, D., & Gladfelter, A. S. (2020). Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. Journal of Cell Biology, 219(7), e201910021.en_US
dc.identifier.urihttps://hdl.handle.net/1912/25992
dc.description© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Gerbich, T. M., McLaughlin, G. A., Cassidy, K., Gerber, S., Adalsteinsson, D., & Gladfelter, A. S. Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. Journal of Cell Biology, 219(7), (2020): e201910021, doi:10.1083/jcb.201910021.en_US
dc.description.abstractBiomolecular condensation is a way of organizing cytosol in which proteins and nucleic acids coassemble into compartments. In the multinucleate filamentous fungus Ashbya gossypii, the RNA-binding protein Whi3 regulates the cell cycle and cell polarity through forming macromolecular structures that behave like condensates. Whi3 has distinct spatial localizations and mRNA targets, making it a powerful model for how, when, and where specific identities are established for condensates. We identified residues on Whi3 that are differentially phosphorylated under specific conditions and generated mutants that ablate this regulation. This yielded separation of function alleles that were functional for either cell polarity or nuclear cycling but not both. This study shows that phosphorylation of individual residues on molecules in biomolecular condensates can provide specificity that gives rise to distinct functional identities in the same cell.en_US
dc.description.sponsorshipThe work was supported by National Institutes of Health grant R01-GM-081506.en_US
dc.publisherRockefeller University Pressen_US
dc.relation.urihttps://doi.org/10.1083/jcb.201910021
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titlePhosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarityen_US
dc.typeArticleen_US
dc.identifier.doi10.1083/jcb.201910021


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