Show simple item record

dc.contributor.authorYang, Zhenye  Concept link
dc.contributor.authorLoncarek, Jadranka  Concept link
dc.contributor.authorKhodjakov, Alexey  Concept link
dc.contributor.authorRieder, Conly L.  Concept link
dc.date.accessioned2008-12-22T15:55:19Z
dc.date.available2008-12-22T15:55:19Z
dc.date.issued2008-04-04
dc.identifier.urihttps://hdl.handle.net/1912/2592
dc.descriptionAuthor Posting. © The Author(s), 2008. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Cell Biology 10 (2008): 748-751, doi:10.1038/ncb1738.en
dc.description.abstractUsing laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We find that doubling the chromosome number adds ~10 minutes to a 20 minute division while doubling the number of centrosomes adds ~30 minutes more, and extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non genetic means and extra chromosomes and centrosomes likely contribute to the elevated mitotic index seen in many tumors.en
dc.description.sponsorshipThis work was supported by National Institutes of General Medical Sciences grants 40198 (to C.L.R.) and 59363 (to A.K.).en
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.relation.urihttps://doi.org/10.1038/ncb1738
dc.subjectMitosisen
dc.subjectCentrosomesen
dc.subjectChromosomesen
dc.subjectCanceren
dc.subjectSpindle assembly checkpointen
dc.titleExtra centrosomes and/or chromosomes prolong mitosis in human cellsen
dc.typePreprinten


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record