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dc.contributor.authorMcCoy, Matthew J.  Concept link
dc.contributor.authorFire, Andrew Z.  Concept link
dc.date.accessioned2020-06-10T20:05:52Z
dc.date.available2020-06-10T20:05:52Z
dc.date.issued2020-05-14
dc.identifier.citationMcCoy, M. J., & Fire, A. Z. (2020). Intron and gene size expansion during nervous system evolution. BMC Genomics, 21(1), 360.en_US
dc.identifier.urihttps://hdl.handle.net/1912/25843
dc.description© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in McCoy, M. J., & Fire, A. Z. Intron and gene size expansion during nervous system evolution. BMC Genomics, 21(1), (2020): 360, doi:10.1186/s12864-020-6760-4.en_US
dc.description.abstractBackground The evolutionary radiation of animals was accompanied by extensive expansion of gene and genome sizes, increased isoform diversity, and complexity of regulation. Results Here we show that the longest genes are enriched for expression in neuronal tissues of diverse vertebrates and of invertebrates. Additionally, we show that neuronal gene size expansion occurred predominantly through net gains in intron size, with a positional bias toward the 5′ end of each gene. Conclusions We find that intron and gene size expansion is a feature of many genes whose expression is enriched in nervous systems. We speculate that unique attributes of neurons may subject neuronal genes to evolutionary forces favoring net size expansion. This process could be associated with tissue-specific constraints on gene function and/or the evolution of increasingly complex gene regulation in nervous systems.en_US
dc.description.sponsorshipThis study was supported by the following programs, grants, and fellowships: 2018 Grass Fellowship in Neuroscience (Grass Foundation), 2019 Whitman Fellowship at the Marine Biological Laboratory, and the Stanford Genomics Training Program (5T32HG000044–22; PI: M. Snyder) to MJM, and R01GM37706/R35GM130366 to AZF. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.publisherBMCen_US
dc.relation.urihttps://doi.org/10.1186/s12864-020-6760-4
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGenome evolutionen_US
dc.subjectGene sizeen_US
dc.subjectIntron sizeen_US
dc.subjectNervous system evolutionen_US
dc.subjectLong genesen_US
dc.subjectLong intronsen_US
dc.titleIntron and gene size expansion during nervous system evolutionen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12864-020-6760-4


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International