A cerebellum-like circuit in the lateral line system of fish cancels mechanosensory input associated with its own movements
MetadataShow full item record
KeywordCerebellum-like; Mechanosensory lateral line; Predictive cancellation; Reafference; Elasmobranch; Sensory system
An animal's own movement exerts a profound impact on sensory input to its nervous system. Peripheral sensory receptors do not distinguish externally generated stimuli from stimuli generated by an animal's own behavior (reafference) – although the animal often must. One way that nervous systems can solve this problem is to provide movement-related signals (copies of motor commands and sensory feedback) to sensory systems, which can then be used to generate predictions that oppose or cancel out sensory responses to reafference. Here, we studied the use of movement-related signals to generate sensory predictions in the lateral line medial octavolateralis nucleus (MON) of the little skate. In the MON, mechanoreceptive afferents synapse on output neurons that also receive movement-related signals from central sources, via a granule cell parallel fiber system. This parallel fiber system organization is characteristic of a set of so-called cerebellum-like structures. Cerebellum-like structures have been shown to support predictive cancellation of reafference in the electrosensory systems of fish and the auditory system of mice. Here, we provide evidence that the parallel fiber system in the MON can generate predictions that are negative images of (and therefore cancel) sensory input associated with respiratory and fin movements. The MON, found in most aquatic vertebrates, is probably one of the most primitive cerebellum-like structures and a starting point for cerebellar evolution. The results of this study contribute to a growing body of work that uses an evolutionary perspective on the vertebrate cerebellum to understand its functional diversity in animal behavior.
Author Posting. © Company of Biologists, 2020. This article is posted here by permission of Company of Biologists for personal use, not for redistribution. The definitive version was published in Journal of Experimental Biology 223 (2020): jeb.204438, doi:10.1242/jeb.204438.
The publisher requires that this item be embargoed until 2021-01-17. Please check back after 2021-01-17.
Suggested CitationPerks, K. E., Krotinger, A., & Bodznick, D. (2020). A cerebellum-like circuit in the lateral line system of fish cancels mechanosensory input associated with its own movements. Journal of Experimental Biology, 223, jeb.204438.
Showing items related by title, author, creator and subject.
Rapo, Mark A. (Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 2009-02)The lateral line system on fish has been found to aid in schooling behavior, courtship communication, active and passive hydrodynamic imaging, and prey detection. The most widely used artificial prey stimulus has been ...
Aging of marine organic matter during cross-shelf lateral transport in the Benguela upwelling system revealed by compound-specific radiocarbon dating Mollenhauer, Gesine; Inthorn, Maik; Vogt, Thomas; Zabel, Matthias; Sinninghe Damste, Jaap S.; Eglinton, Timothy I. (American Geophysical Union, 2007-09-18)Organic matter accumulation and burial on the Namibian shelf and upper slope are spatially heterogeneous and strongly controlled by lateral transport in subsurface nepheloid layers. Much of the material deposited in ...
Electrical synapses enhance and accelerate interneuron recruitment in response to coincident and sequential excitation Alcami, Pepe (Frontiers Media, 2018-06-19)Electrical synapses are ubiquitous in interneuron networks. They form intercellular pathways, allowing electrical currents to leak between coupled interneurons. I explored the impact of electrical coupling on the integration ...