GiardiaDB and TrichDB : integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis
Brunk, Brian P.
Carlton, Jane M.
Harb, Omar S.
Kissinger, Jessica C.
Miller, John A.
Morrison, Hilary G.
Pinney, Deborah F.
Roos, David S.
Stoeckert, Christian J.
MetadataShow full item record
GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the EuPathDB (http://EuPathDB.org) family of functional genomic databases. GiardiaDB and TrichDB employ the same framework as other EuPathDB sites (CryptoDB, PlasmoDB and ToxoDB), supporting fully integrated and searchable databases. Genomic-scale data available via these resources may be queried based on BLAST searches, annotation keywords and gene ID searches, GO terms, sequence motifs and other protein characteristics. Functional queries may also be formulated, based on transcript and protein expression data from a variety of platforms. Phylogenetic relationships may also be interrogated. The ability to combine the results from independent queries, and to store queries and query results for future use facilitates complex, genome-wide mining of functional genomic data.
© 2008 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. The definitive version was published in Nucleic Acids Research 37 (2009): D526-D530, doi:10.1093/nar/gkn631.
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/2.0/uk/
Showing items related by title, author, creator and subject.
Prabhu, Anjali; Morrison, Hilary G.; Martinez, Charles R.; Adam, Rodney D. (2006-12-04)Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with ...
Lauwaet, Tineke; Davids, Barbara J.; Torres-Escobar, Ascencion; Birkeland, Shanda R.; Cipriano, Michael J.; Preheim, Sarah P.; Palm, Daniel; Svard, Staffan G.; McArthur, Andrew G.; Gillin, Frances D. (2006-12-06)The ability of Giardia lamblia to undergo two distinct differentiations in response to physiologic stimuli is central to its pathogenesis. The giardial cytoskeleton changes drastically during encystation and excystation. ...
The transcriptional response to encystation stimuli in Giardia lamblia is restricted to a small set of genes Morf, Laura; Spycher, Cornelia; Rehrauer, Hubert; Fournier, Catharine Aquino; Morrison, Hilary G.; Hehl, Adrian B. (2010-07)The protozoan parasite Giardia lamblia undergoes stage-differentiation in the small intestine of the host to an environmentally resistant and infectious cyst. Encystation involves secretion of an extracellular matrix ...