BioCurrents Research Center

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The BioCurrents Research Center (BRC) is a resource of the National Institutes of Health (NIH), part of the Biomedical Technology division of the National Center for Research Resources.

The emphasis of the BRC is on the physiology of cellular transport mechanisms, particularly as they influence the boundary conditions in the media adjacent to the plasma membrane. To this end we develop new microsensor technologies that operate in a self-referencing mode. We offer access to ion-selective, electrochemical and biosensor devices, coupled to advanced imaging techniques and electrophysiological approaches, combinations unique to the BRC.

Recent Submissions

Title: Dissecting the determinants of light sensitivity in amphioxus microvillar photoreceptors : possible evolutionary implications for melanopsin signaling Author: Ferrer, Camilo; Malagon, Gerardo; Gomez, Maria del Pilar; Nasi, Enrico Date: 2012-12-12
Title: Melanopsin-expressing amphioxus photoreceptors transduce light via a phospholipase C signaling cascade Author: Angueyra, Juan Manuel; Pulido, Camila; Malagon, Gerardo; Nasi, Enrico; Gomez, Maria del Pilar Date: 2012-01-03
Title: Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase Author: Alavian, Kambiz N.; Li, Hongmei; Collis, Leon P.; Bonanni, Laura; Zeng, Lu; Sacchetti, Silvio; Lazrove, Emma; Nabili, Panah; Flaherty, Benjamin; Graham, Morven; Chen, Yingbei; Messerli, Shanta M.; Mariggio, Maria A.; Rahner, Christoph; McNay, Ewan; Shore, Gordon; Smith, Peter J. S.; Hardwick, J. Marie; Jonas, Elizabeth A. Date: 2011-06
Title: Regeneration in the era of functional genomics and gene network analysis Author: Smith, Joel; Morgan, Jennifer R.; Zottoli, Steven J.; Smith, Peter J. S.; Buxbaum, Joseph D.; Bloom, Ona E. Date: 2011-08
Title: Dielectrophoretic tweezer for isolating and manipulating target cells Author: Menachery, Anoop; Graham, David M.; Messerli, Shanta M.; Pethig, Ronald; Smith, Peter J. S. Date: 2010-06-03
Title: Arrestin in ciliary invertebrate photoreceptors : molecular identification and functional analysis in vivo Author: Gomez, Maria del Pilar; Espinosa, Lady; Ramirez, Nelson; Nasi, Enrico Date: 2011-02-02
Title: Construction, Theory, and Practical Considerations for using Self-referencing of Ca2+-Selective Microelectrodes for Monitoring Extracellular Ca2+ Gradients Author: Messerli, Mark A.; Smith, Peter J. S. Date: 2010-10
Title: Windows to cell function and dysfunction : signatures written in the boundary layers Author: Smith, Peter J. S.; Collis, Leon P.; Messerli, Mark A. Date: 2010-01-26
Title: Calcium-independent, cGMP-mediated light adaptation in invertebrate ciliary photoreceptors Author: Gomez, Maria del Pilar; Nasi, Enrico Date: 2005-02-23
Title: Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility Author: Messerli, Shanta M.; Kasinathan, Ravi S.; Morgan, William; Spranger, Stefani; Greenberg, Robert M. Date: 2009-04-28
Title: A direct signaling role for phosphatidylinositol 4,5-bisphosphate (PIP2) in the visual excitation process of microvillar receptors Author: Gomez, Maria del Pilar; Nasi, Enrico Date: 2005-03-01
Title: Modulation of the actin cytoskeleton via gelsolin regulates aacuolar H+-ATPase recycling Author: Beaulieu, Valerie; Da Silva, Nicolas; Pastor-Soler, Nuria; Brown, Christopher R.; Smith, Peter J. S.; Brown, Dennis; Breton, Sylvie Date: 2004-12-09
Title: Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me) Author: Graf, Solomon A.; Haigh, Sarah E.; Corson, Erica D.; Shirihai, Orian S. Date: 2004-06-23
Title: Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase : identification of the enzyme as thioredoxin reductase Author: Gray, Joshua P.; Heck, Diane E.; Mishin, Vladimir; Smith, Peter J. S.; Hong, Jun-Yan; Thiruchelvam, Mona; Cory-Slechta, Deborah A.; Laskin, Debra L.; Laskin, Jeffrey D. Date: 2007-01-17
Title: Ion trapping with fast-response ion-selective microelectrodes enhances detection of extracellular ion channel gradients Author: Messerli, Mark A.; Collis, Leon P.; Smith, Peter J. S. Date: 2008-11
Title: Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into three-dimensional pseudo-islet constructs Author: Pethig, Ronald; Menachery, Anoop; Heart, E.; Sanger, R. H.; Smith, Peter J. S. Date: 2007-11-14
Title: Atypical properties of a conventional calcium channel β subunit from the platyhelminth Schistosoma mansoni Author: Salvador-Recatala, Vicenta; Schneider, Toni; Greenberg, Robert M. Date: 2008-03-26
Title: On the gating mechanisms of the light-dependent conductance in Pecten hyperpolarizing photoreceptors : does light remove inactivation in voltage-dependent K channels? Author: Gomez, Maria del Pilar; Nasi, Enrico Date: 2005-04-11
Title: Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate Author: Kreitzer, Matthew A.; Collis, Leon P.; Molina, Anthony J. A.; Smith, Peter J. S.; Malchow, Robert Paul Date: 2007-07-30
Title: Electrokinetic measurements of membrane capacitance and conductance for pancreatic β-cells Author: Pethig, Ronald; Jakubek, L. M.; Sanger, R. H.; Heart, E.; Corson, Erica D.; Smith, Peter J. S. Date: 2005-10-31

BioCurrents Research Center

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