Fundulus as the premier teleost model in environmental biology : opportunities for new insights using genomics


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dc.contributor.author Burnett, Karen G.
dc.contributor.author Bain, Lisa J.
dc.contributor.author Baldwin, William S.
dc.contributor.author Callard, Gloria V.
dc.contributor.author Cohen, Sarah
dc.contributor.author Di Giulio, Richard T.
dc.contributor.author Evans, David H.
dc.contributor.author Gomez-Chiarri, Marta
dc.contributor.author Hahn, Mark E.
dc.contributor.author Hoover, Cindi A.
dc.contributor.author Karchner, Sibel I.
dc.contributor.author Katoh, Fumi
dc.contributor.author MacLatchy, Deborah L.
dc.contributor.author Marshall, William S.
dc.contributor.author Meyer, Joel N.
dc.contributor.author Nacci, Diane E.
dc.contributor.author Oleksiak, Marjorie F.
dc.contributor.author Rees, Bernard B.
dc.contributor.author Singer, Thomas D.
dc.contributor.author Stegeman, John J.
dc.contributor.author Towle, David W.
dc.contributor.author Van Veld, Peter A.
dc.contributor.author Vogelbein, Wolfgang K.
dc.contributor.author Whitehead, Andrew
dc.contributor.author Winn, Richard N.
dc.contributor.author Crawford, Douglas L.
dc.date.accessioned 2008-01-22T19:38:26Z
dc.date.available 2008-01-22T19:38:26Z
dc.date.issued 2007-09-01
dc.identifier.uri http://hdl.handle.net/1912/2033
dc.description Author Posting. © Elsevier B.V., 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2 (2007): 257-286, doi:10.1016/j.cbd.2007.09.001. en
dc.description.abstract A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms. en
dc.description.sponsorship This material is based on work supported by grants from the National Science Foundation DBI-0420504 (LJB), OCE 0308777 (DLC, RNW, BBR), BES-0553523 (AW), IBN 0236494 (BBR), IOB-0519579 (DHE), IOB-0543860 (DWT), FSML-0533189 (SC); National Institute of Health NIEHS P42-ES007381(GVC, MEH), P42-ES10356 (RTD), ES011588 (MFO); and NCRR P20 RR-016463 (DWT); Natural Sciences and Engineering Research Council of Canada Discovery (DLM, TDS, WSM) and Collaborative Research and Development Programs (DLM); NOAA/National Sea Grant NA86RG0052 (LJB), NA16RG2273 (SIK, MEH,GVC, JJS); Environmental Protection Agency U91620701 (WSB), R82902201(SC) and EPA’s Office of Research and Development (DEN). en
dc.format.mimetype application/pdf
dc.language.iso en_US en
dc.relation.uri http://dx.doi.org/10.1016/j.cbd.2007.09.001
dc.subject Fundulus heteroclitus en
dc.subject Physiological genomics en
dc.subject Ecological genomics en
dc.subject Evolutionary genomics en
dc.subject Toxicogenomics en
dc.subject Environmental genomics en
dc.title Fundulus as the premier teleost model in environmental biology : opportunities for new insights using genomics en
dc.type Preprint en

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