Design and function of superfast muscles : new insights into the physiology of skeletal muscle
Rome, Lawrence C.
MetadataShow full item record
KeywordParvalbumin; Ca2+ release; Ca2+ uptake; Cross-bridges; Adaptation; Sound production; Whitman Center
Superfast muscles of vertebrates power sound production. The fastest, the swimbladder muscle of toadfish, generates mechanical power at frequencies in excess of 200 Hz. To operate at these frequencies, the speed of relaxation has had to increase approximately 50-fold. This increase is accomplished by modifications of three kinetic traits: (a) a fast calcium transient due to extremely high concentration of sarcoplasmic reticulum (SR)-Ca2+ pumps and parvalbumin, (b) fast off-rate of Ca2+ from troponin C due to an alteration in troponin, and (c) fast cross-bridge detachment rate constant (g, 50 times faster than that in rabbit fast-twitch muscle) due to an alteration in myosin. Although these three modifications permit swimbladder muscle to generate mechanical work at high frequencies (where locomotor muscles cannot), it comes with a cost: The high g causes a large reduction in attached force-generating cross-bridges, making the swimbladder incapable of powering low-frequency locomotory movements. Hence the locomotory and sound-producing muscles have mutually exclusive designs.
First published online as a Review in Advance on October 24, 2005. (Some corrections may occur before final publication online and in print)Author Posting. © Annual Reviews, 2005. This article is posted here by permission of Annual Reviews for personal use, not for redistribution. The definitive version was published in Annual Review of Physiology 68 (2006): 22.1-22.29, doi:10.1146/annurev.physiol.68.040104.105418.
Suggested CitationArticle: Rome, Lawrence C., "Design and function of superfast muscles : new insights into the physiology of skeletal muscle", Annual Review of Physiology 68 (2006): 22.1-22.29, DOI:10.1146/annurev.physiol.68.040104.105418, https://hdl.handle.net/1912/200
Showing items related by title, author, creator and subject.
Effects of preservation methods of muscle tissue from upper-trophic level reef fishes on stable isotope values (δ13C and δ15N) Stallings, Christopher D.; Nelson, James A.; Rozar, Katherine L.; Adams, Charles S.; Wall, Kara R.; Switzer, Theodore S.; Winner, Brent L.; Hollander, David J. (PeerJ, 2015-03-26)Research that uses stable isotope analysis often involves a delay between sample collection in the field and laboratory processing, therefore requiring preservation to prevent or reduce tissue degradation and associated ...
Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder Nelson, Frank E.; Hollingworth, Stephen; Rome, Lawrence C.; Baylor, Stephen M. (Rockefeller University Press, 2014-04-14)The mating call of the Atlantic toadfish is generated by bursts of high-frequency twitches of the superfast twitch fibers that surround the swimbladder. At 16°C, a calling period can last several hours, with individual ...
Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris) Moore, Colby D.; Crocker, Daniel E.; Fahlman, Andreas; Moore, Michael J.; Willoughby, Darryn S.; Robbins, Kathleen A.; Kanatous, Shane B.; Trumble, Stephen J. (Frontiers Media, 2014-06-10)Northern elephant seals (Mirounga angustirostris) (NES) are known to be deep, long-duration divers and to sustain long-repeated patterns of breath-hold, or apnea. Some phocid dives remain within the bounds of aerobic ...