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    Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

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    IJParafinalversion060607 with figs.pdf (445.9Kb)
    Date
    2006-12-04
    Author
    Prabhu, Anjali  Concept link
    Morrison, Hilary G.  Concept link
    Martinez, Charles R.  Concept link
    Adam, Rodney D.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/1698
    As published
    https://doi.org/10.1016/j.ijpara.2006.12.011
    Keyword
     Giardia lamblia; Telomere; Subtelomeric region; vsp; Retroposon 
    Abstract
    Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.
    Description
    Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in International Journal for Parasitology 37 (2007): 503-513, doi:10.1016/j.ijpara.2006.12.011.
    Collections
    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Preprint: Prabhu, Anjali, Morrison, Hilary G., Martinez, Charles R., Adam, Rodney D., "Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6", 2006-12-04, https://doi.org/10.1016/j.ijpara.2006.12.011, https://hdl.handle.net/1912/1698
     

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