Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6
Date
2006-12-04Metadata
Show full item recordCitable URI
https://hdl.handle.net/1912/1698As published
https://doi.org/10.1016/j.ijpara.2006.12.011Keyword
Giardia lamblia; Telomere; Subtelomeric region; vsp; RetroposonAbstract
Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.
Description
Author Posting. © The Author(s), 2007. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in International Journal for Parasitology 37 (2007): 503-513, doi:10.1016/j.ijpara.2006.12.011.
Related items
Showing items related by title, author, creator and subject.
-
GiardiaDB and TrichDB : integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis
(Oxford University Press, 2008-09-29)GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the EuPathDB (http://EuPathDB.org) ... -
Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation
(2006-12-06)The ability of Giardia lamblia to undergo two distinct differentiations in response to physiologic stimuli is central to its pathogenesis. The giardial cytoskeleton changes drastically during encystation and excystation. ... -
Optical map of the genotype A1 WB C6 Giardia lamblia genome isolate
(2011-07)The Giardia lamblia genome consists of 12 Mb divided among 5 chromosomes ranging in size from approximately 1 to 4 Mb. The assembled contigs of the genotype A1 isolate, WB, were previously mapped along the 5 chromosomes ...
