RSS 1.0Neuroscience Institute
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The Neuroscience Institute continues a long and rich tradition of neuroscience at the Marine Biological Laboratory. It was here that Nobelist H. Keffer Hartline and Stephen Kuffler performed their groundbreaking studies of single nerve fibers that revealed the receptive field organization of retinal neurons. It was also here that LW Williams (1910) and later JZ Young (1932) discovered the squid giant axon on which KC Cole (1937) then made the first measurements of the resistance changes underlying the nervous impulse.
Recent Submissions
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Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes
(2007-03-30)We measured the concentration dependence of the ability of rats to identify odorants and compared these results with the calcium signals in the nerve terminals of the olfactory receptor neurons. Odorant identification ... -
Structural domains involved in the regulation of transmitter release by synapsins
(Society for Neuroscience, 2005-03-09)Synapsins are a family of neuron-specific phosphoproteins that regulate neurotransmitter release by associating with synaptic vesicles. Synapsins consist of a series of conserved and variable structural domains of unknown ... -
Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons
(Society for Neuroscience, 2005-03-16)Ca2+ signals in neurons use specific temporal and spatial patterns to encode unambiguous information about crucial cellular functions. To understand the molecular basis for initiation and propagation of inositol ... -
Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release
(2007-08-01)The time at which the N-ethylmaleimide-sensitive factor (NSF) acts during synaptic vesicle trafficking was identified by time-controlled perturbation of NSF function with a photo-activatable inhibitory peptide. Photolysis ... -
Squid (Loligo pealei) giant fiber system : a model for studying neurodegeneration and dementia?
(Marine Biological Laboratory, 2006-06)In many neurodegenerative disorders that lead to memory loss and dementia, the brain pathology responsible for neuronal loss is marked by accumulations of proteins in the form of extracellular plaques and intracellular ...
