Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
Ferguson, D. J. P.
Hajduk, Stephen L.
Day, K. P.
MetadataShow full item record
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.
Suggested CitationParasitology 128 (2004): 577-584
Showing items related by title, author, creator and subject.
Li, Ming; Trowbridge, John H.; Geyer, W. Rockwell (American Meteorological Society, 2008-02)Stratification and turbulent mixing exhibit a flood–ebb tidal asymmetry in estuaries and continental shelf regions affected by horizontal density gradients. The authors use a large-eddy simulation (LES) model to investigate ...
Density currents in the Chicago River : characterization, effects on water quality, and potential sources Jackson, P. Ryan; Garcia, Carlos M.; Oberg, Kevin A.; Johnson, Kevin K.; Garcia, Marcelo H. (2008-03)Bidirectional flows in a river system can occur under stratified flow conditions and in addition to creating significant errors in discharge estimates, the upstream propagating currents are capable of transporting contaminants ...
High-frequency acoustic scattering from turbulent oceanic microstructure : the importance of density fluctuations Lavery, Andone C.; Schmitt, Raymond W.; Stanton, Timothy K. (Acoustical Society of America, 2003-11)Acoustic scattering techniques provide a unique and powerful tool to remotely investigate the physical properties of the ocean interior over large spatial and temporal scales. With high-frequency acoustic scattering it is ...