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    Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro

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    Imrie Light.pdf (174.8Kb)
    Date
    2004-05-13
    Author
    Imrie, H.  Concept link
    Ferguson, D. J. P.  Concept link
    Carter, M.  Concept link
    Drain, J.  Concept link
    Schiflett, A.  Concept link
    Hajduk, Stephen L.  Concept link
    Day, K. P.  Concept link
    Metadata
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    Citable URI
    https://hdl.handle.net/1912/161
    As published
    https://doi.org/10.1017/S0031182004005025
    DOI
    10.1017/S0031182004005025
    Keyword
     Plasmodium falciparum; High density lipoprotein 
    Abstract
    Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
    Description
    Author Posting. © Cambridge University Press, 2004. This article is posted here by permission of Cambridge University Press for personal use, not for redistribution. The definitive version was published in Parasitology 128 (2004): 577-584, doi:10.1017/S0031182004005025.
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    • Josephine Bay Paul Center in Comparative Molecular Biology and Evolution
    Suggested Citation
    Parasitology 128 (2004): 577-584
     

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