Historical perspecitive on lead biokinetic models
MetadataShow full item record
A historical review of the development of biokinetic model of lead is presented. Biokinetics is interpreted narrowly to mean only physiologic processes happening within the body. Proceeding chronologically, for each epoch, the measurements of lead in the body are presented along with mathematical models in an attempt to trace the convergence of observations from two disparate fields--occupational medicine and radiologic health--into some unified models. Kehoe's early balance studies and the use of radioactive lead tracers are presented. The 1960s saw the joint application of radioactive lead techniques and simple compartmental kinetic models used to establish the exchange rates and residence times of lead in body pools. The applications of stable isotopes to questions of the magnitudes of respired and ingested inputs required the development of a simple three-pool model. During the 1980s more elaborate models were developed. One of their key goals was the establishment of the dose-response relationship between exposure to lead and biologic precursors of adverse health effects.
Environmental Health Perspectives Supplements is a publication of the United States government. Publication of Environmental Health Perspectives Supplements lies in the public domain and is therefore without copyright. The definitive version was published in Environmental Health Perspectives Supplements Volume 106 (1998): 1461-1465.
Showing items related by title, author, creator and subject.
Rastetter, Edward B. (2016-11)I draw a distinction between Modeling for Numbers, which aims to address how much, when, and where questions, and Modeling for Understanding, which aims to address how and why questions. For-numbers models are often ...
Historical and idealized climate model experiments : an intercomparison of Earth system models of intermediate complexity Eby, Michael; Weaver, Andrew J.; Alexander, K.; Zickfeld, K.; Abe-Ouchi, A.; Cimatoribus, A. A.; Crespin, E.; Drijfhout, S. S.; Edwards, N. R.; Eliseev, A. V.; Feulner, G.; Fichefet, T.; Forest, C. E.; Goosse, H.; Holden, P. B.; Joos, Fortunat; Kawamiya, M.; Kicklighter, David W.; Kienert, H.; Matsumoto, K.; Mokhov, I. I.; Monier, Erwan; Olsen, S. M.; Pedersen, J. O. P.; Perrette, M.; Philippon-Berthier, G.; Ridgwell, Andy; Schlosser, A.; Schneider von Deimling, T.; Shaffer, G.; Smith, R. S.; Spahni, R.; Sokolov, Andrei P.; Steinacher, M.; Tachiiri, K.; Tokos, K.; Yoshimori, M.; Zeng, Ning; Zhao, F. (Copernicus Publications on behalf of the European Geosciences Union, 2013-05-16)Both historical and idealized climate model experiments are performed with a variety of Earth system models of intermediate complexity (EMICs) as part of a community contribution to the Intergovernmental Panel on Climate ...
Short-term dispersal of Fukushima-derived radionuclides off Japan : modeling efforts and model-data intercomparison Rypina, Irina I.; Jayne, Steven R.; Yoshida, Sachiko; Macdonald, Alison M.; Douglass, Elizabeth M.; Buesseler, Ken O. (Copernicus Publications on behalf of the European Geosciences Union, 2013-07-24)The Great East Japan Earthquake and tsunami that caused a loss of power at the Fukushima nuclear power plants (FNPP) resulted in emission of radioactive isotopes into the atmosphere and the ocean. In June of 2011, an ...