Historical perspecitive on lead biokinetic models
MetadataShow full item record
A historical review of the development of biokinetic model of lead is presented. Biokinetics is interpreted narrowly to mean only physiologic processes happening within the body. Proceeding chronologically, for each epoch, the measurements of lead in the body are presented along with mathematical models in an attempt to trace the convergence of observations from two disparate fields--occupational medicine and radiologic health--into some unified models. Kehoe's early balance studies and the use of radioactive lead tracers are presented. The 1960s saw the joint application of radioactive lead techniques and simple compartmental kinetic models used to establish the exchange rates and residence times of lead in body pools. The applications of stable isotopes to questions of the magnitudes of respired and ingested inputs required the development of a simple three-pool model. During the 1980s more elaborate models were developed. One of their key goals was the establishment of the dose-response relationship between exposure to lead and biologic precursors of adverse health effects.
Environmental Health Perspectives Supplements is a publication of the United States government. Publication of Environmental Health Perspectives Supplements lies in the public domain and is therefore without copyright. The definitive version was published in Environmental Health Perspectives Supplements Volume 106 (1998): 1461-1465.
Showing items related by title, author, creator and subject.
Model behavior and sensitivity in an application of the Cohesive Bed Component of the Community Sediment Transport Modeling System for the York River estuary, VA, USA Fall, Kelsey A.; Harris, Courtney K.; Friedrichs, Carl T.; Rinehimer, J. Paul; Sherwood, Christopher R. (MDPI AG, 2014-05-19)The Community Sediment Transport Modeling System (CSTMS) cohesive bed sub-model that accounts for erosion, deposition, consolidation, and swelling was implemented in a three-dimensional domain to represent the York River ...
Desert dust and anthropogenic aerosol interactions in the Community Climate System Model coupled-carbon-climate model Mahowald, Natalie M.; Lindsay, Keith; Rothenberg, D.; Doney, Scott C.; Moore, J. Keith; Thornton, Peter E.; Randerson, James T.; Jones, C. D. (Copernicus Publications on behalf of the European Geosciences Union, 2011-02-15)Coupled-carbon-climate simulations are an essential tool for predicting the impact of human activity onto the climate and biogeochemistry. Here we incorporate prognostic desert dust and anthropogenic aerosols into the ...
Recent advances in Arctic ocean studies employing models from the Arctic Ocean Model Intercomparison Project Proshutinsky, Andrey; Aksenov, Yevgeny; Kinney, Jaclyn Clement; Gerdes, Rudiger; Golubeva, Elena; Holland, David; Holloway, Greg; Jahn, Alexandra; Johnson, Mark; Popova, Ekaterina; Steele, Michael; Watanabe, Eiji (Oceanography Society, 2011-09)Observational data show that the Arctic Ocean has significantly and rapidly changed over the last few decades, which is unprecedented in the observational record. Air and water temperatures have increased, sea ice volume ...