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dc.contributor.authorMarkert, Stephanie
dc.contributor.authorArndt, Cordelia
dc.contributor.authorFelbeck, Horst
dc.contributor.authorBecher, Dorte
dc.contributor.authorSievert, Stefan M.
dc.contributor.authorHugler, Michael
dc.contributor.authorAlbrecht, Dirk
dc.contributor.authorRobidart, Julie
dc.contributor.authorBench, Shellie
dc.contributor.authorFeldman, Robert A.
dc.contributor.authorHecker, Michael
dc.contributor.authorSchweder, Thomas
dc.date.accessioned2007-02-28T14:25:14Z
dc.date.available2007-02-28T14:25:14Z
dc.date.issued2006-11-14
dc.identifier.urihttp://hdl.handle.net/1912/1514
dc.descriptionAuthor Posting. © The Authors, 2006. This is the author's version of the work. It is posted here by permission of AAAS for personal use, not for redistribution. The definitive version was published in Science 315 (2007): 247-250, doi:10.1126/science.1132913.en
dc.description.abstractThe bacterial endosymbiont of the deep-sea tube worm Riftia pachyptila has never been successfully cultivated outside its host. In the absence of cultivation data we have taken a proteomic approach based on the metagenome sequence to study the metabolism of this peculiar microorganism in detail. As one result, we found that three major sulfide oxidation proteins constitute ~12% of the total cytosolic proteome, highlighting the essential role of these enzymes for the symbiont’s energy metabolism. Unexpectedly, the symbiont uses the reductive tricarboxylic acid (TCA) cycle in addition to the previously identified Calvin cycle for CO2 fixation.en
dc.description.sponsorshipThis work was supported by the DFG, grant Schw595/3-1. Other funding sources were: NSF (OCE 04-52333) and NASA Astrobiology Institute (NNA04CC04A) for SMS, MH: postdoctoral scholarship from WHOI, HF: Academic Senate (RF811S and RE518S).en
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dc.language.isoen_USen
dc.relation.urihttps://doi.org/10.1126/science.1132913
dc.titlePhysiological proteomics of the uncultured endosymbiont of Riftia pachyptilaen
dc.title.alternativeApproaching the uncultured endosymbiont of Riftia pachyptila by physiological proteomicsen
dc.typePreprinten


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