Now showing items 1-5 of 5
Identification of DeltaN isoform and polyadenylation site choice variants in molluscan p63/p73 -like homologues
The p53 family of transcription factors has been implicated in many vertebrate cancers. Altered p53 and p73 protein expression observed in leukemic cells of mollusks suggests that these transcription factors might be ...
The nerve hemoglobin of the bivalve mollusc Spisula solidissima : molecular cloning, ligand binding studies, and phylogenetic analysis
(American Society for Biochemistry and Molecular Biology, 2005-12-13)
Members of the hemoglobin (Hb) superfamily are present in nerve tissue of several vertebrate and invertebrate species. In vertebrates they display hexacoordinate heme iron atoms and are typically expressed at low levels ...
Detecting p53 family proteins in haemocytic leukemia cells of Mytilus edulis from Pictou Harbour, Nova Scotia, Canada
(National Research Council Canada, 2005-09-01)
Evaluating patterns of expression of p53-related proteins in cells is a novel approach in defining environmentally linked diseases. We have examined the induction of haemocytic leukemia in Mytilus edulis by municipal and ...
A New invertebrate member of the p53 gene family is developmentally expressed and responds to polychlorinated biphenyls
(National Institute of Environmental Health Sciences, 2002-03-07)
The cell-cycle checkpoint protein p53 both directs terminal differentiation and protects embryos from DNA damage. To study invertebrate p53 during early development, we identified three differentially expressed p53 family ...
Identification and phylogenetic comparison of p53 in two distinct mussel species (Mytilus)
The extent to which humans and wildlife are exposed to anthropogenic challenges is an important focus of environmental research. Potential use of p53 gene family marker(s) for aquatic environmental effects monitoring is ...