Regulation of cytokinesis by spindle-pole bodies
MetadataShow full item record
In the fission yeast Schizosaccharomyces pombe, cytokinesis is thought to be controlled by the daughter spindle pole body (SPB) through a regulatory pathway, the Septation Initiation Network (SIN). Here we demonstrate that laser ablation of both but not a single SPB results in cytokinesis failure. Ablation of just the daughter SPB often leads to activation of the SIN on the mother and successful cytokinesis. Thus, either SPB can drive cytokinesis.
Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Cell Biology 8 (2006): 891-893, doi:10.1038/ncb1449.