Now showing items 1-10 of 146
Kinetic framework of spindle assembly checkpoint signaling
The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles1, 2. Here, we investigated SAC signaling kinetics in response to acute detachment of individual ...
Auditory evoked potential audiometry in fish
A recent survey lists more than 100 papers utilizing the auditory evoked potential (AEP) recording technique for studying hearing in fishes. More than 95 % of these AEP-studies were published after Kenyon et al. introduced ...
Time, impact, and the need for digital history and philosophy of science
(University of Chicago, 2016-06)
Embryos, microscopes, and society
Embryos have different meanings for different people and in different contexts. Seen under the microscope, the biological embryo starts out as one cell and then becomes a bunch of cells. Gradually these divide and differentiate ...
Phase separation of signaling molecules promotes T cell receptor signal transduction
Activation of various cell surface receptors triggers the reorganization of downstream signaling molecules into micron- or submicron-sized clusters. However, the functional consequences of such clustering has been unclear. ...
Presynaptic nanodomains : a tale of two synapses
(Frontiers Media, 2015-01-26)
Here we summarize the evidence from two “giant” presynaptic terminals—the squid giant synapse and the mammalian calyx of Held—supporting the involvement of nanodomain calcium signals in triggering of neurotransmitter ...
Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium
(American Society for Clinical Investigation, 2006-06)
Regulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been linked to many cellular processes and pathological conditions. In the present study, ...
Effects of temperature and diet on the growth rate of year 0 oyster toadfish, Opsanus tau
(Marine Biological Laboratory, 2006-02)
The effects of temperature and diet on the growth of captive year 0 specimens of Opansus tau were examined for two consecutive year classes. The 2001 year class was raised at about 23, 26, or 29°C and provided with live ...
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity : a combined voltage- and calcium-imaging study
The non-linear and spatially inhomogeneous interactions of dendritic membrane potential signals that represent the first step in the induction of activity dependent long-term synaptic plasticity are not fully understood, ...
Polar body formation in Spisula oocytes : function of the peripheral aster
(Marine Biological Laboratory, 2005-08)
Activated Spisula oocytes proceed through meiotic stages rapidly and in near synchrony, providing an excellent system for analyzing polar body formation. Our previous studies suggested that cortical spreading of the metaphase ...