Now showing items 1-2 of 2

  • The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity 

    LaPointe, Nichole E.; Morfini, Gerardo A.; Pigino, Gustavo F.; Gaisina, Irina N.; Kozikowski, Alan P.; Binder, Lester I.; Brady, Scott T. (2008-04)
    The neuropathology of Alzheimer’s disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule-associated protein tau, but the relationship between tau polymerization and neurotoxicity ...
  • Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin 

    Morfini, Gerardo A.; You, Yi-Mei; Pollema, Sarah L.; Kaminska, Agnieszka; Liu, Katherine; Yoshioka, Katsuji; Bjorkblom, Benny; Coffey, Eleanor T.; Bagnato, Carolina; Han, David; Huang, Chun-Fang; Banker, Gary; Pigino, Gustavo F.; Brady, Scott T. (2009-04-28)
    Selected vulnerability of neurons in Huntington’s disease (HD) suggests alterations in a cellular process particularly critical for neuronal function. Supporting this idea, pathogenic Htt (polyQ-Htt) inhibits fast axonal ...