Scores of distinguished biologists from around the world come to the MBL to collaborate and conduct research. They use marine and other organisms as model systems for their research.

These researchers participate in a number of established MBL groups including but not limited to:

  • MBL Summer Research Fellows
  • Dart Scholars
  • Grass Faculty Awardees
  • NeuroImaging Cluster
  • Grass Fellows
  • Whitman Center

Recent Submissions

  • Imaging of dynamic actin remodeling reveals distinct behaviors of head and trunk mesoderm in gastrulating Xenopus laevis 

    Komatsu, Valerie; Doddihal, Viraj; Chang, Chenbei (Caltech Library, 2021-10-14)
    Gastrulation involves coordinated movements of cells, facilitating mesoderm and endoderm internalization and proper patterning of tissues across the germ layers. In Xenopus laevis, head mesoderm migrates collectively along ...
  • Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome 

    Govind, Anitha P.; Jeyifous, Okunola; Russell, Theron A.; Yi, Zola; Weigel, Aubrey V.; Ramaprasad, Abhijit; Newell, Luke; Ramos, William; Valbuena, Fernando M.; Casler, Jason C.; Yan, Jing-Zhi; Glick, Benjamin S.; Swanson, Geoffrey T.; Lippincott-Schwartz, Jennifer; Green, William N. (eLife Sciences Publications, 2021-09-21)
    Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity, and related diseases, but their mechanistic basis and significance are unclear. Here, we observed that ...
  • Frontotemporal lobar dementia mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism 

    Combs, Benjamin; Christensen, Kyle R.; Richards, Collin; Kneynsberg, Andrew; Mueller, Rebecca L.; Morris, Sarah L.; Morfini, Gerardo A.; Brady, Scott T.; Kanaan, Nicholas M. (Society for Neuroscience, 2021-10-04)
    Pathologic tau modifications are characteristic of Alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. Inherited mutations in tau cause early onset frontotemporal lobar dementias ...
  • Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses 

    Li, Shuo; Raychaudhuri, Sumana; Lee, Stephen Alexander; Brockmann, Marisa M.; Wang, Jing; Kusick, Grant; Prater, Christine; Syed, Sarah; Falahati, Hanieh; Ramos, Raul; Bartol, Tomas M.; Hosy, Eric; Watanabe, Shigeki (Nature Research, 2021-01-29)
    Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous ...
  • A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo 

    Hawk, Josh D.; Wisdom, Elias M.; Sengupta, Titas; Kashlan, Zane D.; Colón-Ramos, Daniel (Nature Research, 2021-08-09)
    Chemogenetic and optogenetic tools have transformed the field of neuroscience by facilitating the examination and manipulation of existing circuits. Yet, the field lacks tools that enable rational rewiring of circuits via ...
  • A cross-institutional analysis of the effects of broadening trainee professional development on research productivity 

    Brandt, Patrick D.; Sturzenegger Varvayanis, Susi; Baas, Tracey; Bolgioni, Amanda F.; Alder, Janet; Petrie, Kimberly A.; Dominguez, Isabel; Brown, Abigail M.; Stayart, C. Abigail; Singh, Harinder; Van Wart, Audra; Chow, Christine S.; Mathur, Ambika; Schreiber, Barbara M.; Fruman, David A.; Bowden, Brent; Wiesen, Christopher A.; Golightly, Yvonne M.; Holmquist, Chris E.; Arneman, Daniel; Hall, Joshua D.; Hyman, Linda E.; Gould, Kathleen L.; Chalkley, Roger; Brennwald, Patrick J.; Layton, Rebekah L. (Public Library of Science, 2021-07-15)
    PhD-trained scientists are essential contributors to the workforce in diverse employment sectors that include academia, industry, government, and nonprofit organizations. Hence, best practices for training the future ...
  • Teamwork in the viscous oceanic microscale 

    Kanso, Eva A.; Lopes, Rubens M.; Strickler, J. Rudi; Dabiri, John O.; Costello, John H. (National Academy of Sciences, 2021-07-16)
    Nutrient acquisition is crucial for oceanic microbes, and competitive solutions to solve this challenge have evolved among a range of unicellular protists. However, solitary solutions are not the only approach found in ...
  • NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions 

    Münzer, Patrick; Negro, Roberto; Fukui, Shoichi; di Meglio, Lucas; Aymonnier, Karen; Chu, Long; Cherpokova, Deya; Gutch, Sarah; Sorvillo, Nicoletta; Shi, Lai; Magupalli, Venkat Giri; Weber, Alexander N. R.; Scharf, Rüdiger E.; Waterman, Clare M.; Wu, Hao; Wagner, Denisa D. (Frontiers Media, 2021-03-28)
    Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated ...
  • Post-stroke epileptogenesis is associated with altered intrinsic properties of hippocampal pyramidal neurons leading to increased theta resonance 

    Vera, Jorge; Lippmann, Kristina (Elsevier, 2021-06-10)
    Brain insults like stroke, trauma or infections often lead to blood-brain barrier-dysfunction (BBBd) frequently resulting into epileptogenesis. Affected patients suffer from seizures and cognitive comorbidities that are ...
  • Conserved and unique transcriptional features of pharyngeal arches in the skate (Leucoraja erinacea) and evolution of the jaw 

    Hirschberger, Christine; Sleight, Victoria A.; Criswell, Katharine E.; Clark, Stephen J.; Gillis, J. Andrew (Oxford University Press, 2021-04-27)
    The origin of the jaw is a long-standing problem in vertebrate evolutionary biology. Classical hypotheses of serial homology propose that the upper and lower jaw evolved through modifications of dorsal and ventral gill ...
  • Tau: a signaling hub protein 

    Mueller, Rebecca L.; Combs, Benjamin; Alhadidy, Mohammed M.; Brady, Scott T.; Morfini, Gerardo A.; Kanaan, Nicholas M. (Frontiers Media, 2021-03-19)
    Over four decades ago, in vitro experiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties ...
  • Neuromechanical wave resonance in jellyfish swimming 

    Hoover, Alexander P.; Xu, Nicole W.; Gemmell, Brad J.; Colin, Sean P.; Costello, John H.; Dabiri, John O.; Miller, Laura A. (National Academy of Sciences, 2021-03-16)
    For organisms to have robust locomotion, their neuromuscular organization must adapt to constantly changing environments. In jellyfish, swimming robustness emerges when marginal pacemakers fire action potentials throughout ...
  • HP1 proteins compact DNA into mechanically and positionally stable phase separated domains 

    Keenen, Madeline M.; Brown, David; Brennan, Lucy D.; Renger, Roman; Khoo, Harrison; Carlson, Christopher R.; Huang, Bo; Grill, Stephan W.; Narlikar, Geeta J.; Redding, Sy (eLife Sciences Publications, 2021-03-04)
    In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether ...
  • New species can broaden myelin research: suitability of little skate, Leucoraja erinacea 

    Möbius, Wiebke; Hümmert, Sophie; Ruhwedel, Torben; Kuzirian, Alan M.; Gould, Robert M. (MDPI, 2021-02-11)
    Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination ...
  • Multiple behavior-specific cancellation signals contribute to suppressing predictable sensory reafference in a cerebellum-like structure 

    Lai, Nicole Y.; Bell, Jordan M.; Bodznick, David (The Company of Biologists, 2021-04-15)
    Movement induces sensory stimulation of an animal's own sensory receptors, termed reafference. With a few exceptions, notably vestibular and proprioception, this reafference is unwanted sensory noise and must be selectively ...
  • Defined tau phosphospecies differentially inhibit fast axonal transport through activation of two independent signaling pathways 

    Morris, Sarah L.; Tsai, Ming-Ying; Aloe, Sarah; Bechberger, Karin; König, Svenja; Morfini, Gerardo A.; Brady, Scott T. (Frontiers Media, 2021-01-25)
    Tau protein is subject to phosphorylation by multiple kinases at more than 80 different sites. Some of these sites are associated with tau pathology and neurodegeneration, but other sites are modified in normal tau as well ...
  • Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm 

    Pelletier, James F.; Field, Christine M.; Fürthauer, Sebastian; Sonnett, Matthew; Mitchison, Timothy J. (eLife Sciences Publications, 2020-12-07)
    How bulk cytoplasm generates forces to separate post-anaphase microtubule (MT) asters in Xenopus laevis and other large eggs remains unclear. Previous models proposed that dynein-based, inward organelle transport generates ...
  • Affinity purification of label-free tubulins from xenopus egg extracts 

    Reusch, Sebastian; Biswas, Abin; Hirst, William G.; Reber, Simone (Cell Press, 2020-12-18)
    Cytoplasmic extracts from unfertilized Xenopus eggs have made important contributions to our understanding of microtubule dynamics, spindle assembly, and scaling. Until recently, these in vitro studies relied on the use ...
  • In Vitro reconstitution and imaging of microtubule dynamics by fluorescence and label-free microscopy 

    Hirst, William G.; Kiefer, Christine; Abdosamadi, Mohammad Kazem; Schäffer, Erik; Reber, Simone (Cell Press, 2020-11-24)
    Dynamic microtubules are essential for many processes in the lives of eukaryotic cells. To study and understand the mechanisms of microtubule dynamics and regulation, in vitro reconstitution with purified components has ...
  • Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea 

    Sleight, Victoria A.; Gillis, J. Andrew (eLife Sciences Publications, 2020-11-17)
    Paired fins are a defining feature of the jawed vertebrate body plan, but their evolutionary origin remains unresolved. Gegenbaur proposed that paired fins evolved as gill arch serial homologues, but this hypothesis is now ...

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