Systems Biology of the human microbiome
Peñalver Bernabé, Beatriz
Gilbert, Jack A.
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Recent research has shown that the microbiome—a collection of microorganisms, including bacteria, fungi, and viruses, living on and in a host—are of extraordinary importance in human health, even from conception and development in the uterus. Therefore, to further our ability to diagnose disease, to predict treatment outcomes, and to identify novel therapeutics, it is essential to include microbiome and microbial metabolic biomarkers in Systems Biology investigations. In clinical studies or, more precisely, Systems Medicine approaches, we can use the diversity and individual characteristics of the personal microbiome to enhance our resolution for patient stratification. In this review, we explore several Systems Medicine approaches, including Microbiome Wide Association Studies to understand the role of the human microbiome in health and disease, with a focus on ‘preventive medicine’ or P4 (i.e., personalized, predictive, preventive, participatory) medicine.
© The Author(s), 2017. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Current Opinion in Biotechnology 51 (2018): 146-153, doi:10.1016/j.copbio.2018.01.018.
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Suggested CitationPreprint: Peñalver Bernabé, Beatriz, Cralle, Lauren, Gilbert, Jack A., "Systems Biology of the human microbiome", 2017-09, https://doi.org/10.1016/j.copbio.2018.01.018, https://hdl.handle.net/1912/10477
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