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dc.contributor.authorVianay, Benoit  Concept link
dc.contributor.authorSenger, Fabrice  Concept link
dc.contributor.authorAlamos, Simon  Concept link
dc.contributor.authorAnjur-Dietrich, Maya  Concept link
dc.contributor.authorBearce, Elizabeth  Concept link
dc.contributor.authorCheeseman, Bevan  Concept link
dc.contributor.authorLee, Lisa  Concept link
dc.contributor.authorThéry, Manuel  Concept link
dc.date.accessioned2018-05-11T16:17:43Z
dc.date.available2018-05-11T16:17:43Z
dc.date.issued2017-10-31
dc.identifier.urihttps://hdl.handle.net/1912/10345
dc.descriptionAuthor Posting. © The Author(s), 2017. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in Biology of the Cell 110 (2018):91-96, doi:10.1111/boc.201800006.en_US
dc.description.abstractTissue morphogenesis results from the interplay between cell growth and mechanical forces. While the impact of forces on cell proliferation has been fairly well characterized, the inverse relationship is much less understood. Here we investigated how traction forces vary during cell cycle progression. Cell shape was constrained on micropatterned substrates in order to distinguish variations in cell contractility from cell size increase. We performed traction force measurements of asynchronously dividing cells expressing a cell-cycle reporter, to obtain measurements of contractile forces generated during cell division. We found that forces tend to increase as cells progress through G1, before reaching a plateau in S phase, and then decline during G2. This biphasic behaviour revealed a previously undocumented specific and opposite regulation of cell contractility during each cell cycle stage.en_US
dc.language.isoen_USen_US
dc.relation.urihttps://doi.org/10.1111/boc.201800006
dc.titleVariation in traction forces during cell cycle progressionen_US
dc.typePreprinten_US


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