dc.contributor.author	Geller-McGrath, David
dc.contributor.author	Mara, Paraskevi
dc.contributor.author	Taylor, Gordon T.
dc.contributor.author	Suter, Elizabeth
dc.contributor.author	Edgcomb, Virginia
dc.contributor.author	Pachiadaki, Maria
dc.date.accessioned	2023-09-25T18:39:29Z
dc.date.available	2023-09-25T18:39:29Z
dc.date.issued	2023-02-06
dc.description	© The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Geller-McGrath, D., Mara, P., Taylor, G., Suter, E., Edgcomb, V., & Pachiadaki, M. Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin. Nature Communications, 14(1), (2023): 656, https://doi.org/10.1038/s41467-023-36026-w.
dc.description.abstract	Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition and production of secondary metabolites. Our results indicate that microbes, including understudied clades such as Planctomycetota, potentially produce a wide range of secondary metabolites in these anoxic/euxinic waters.
dc.description.sponsorship	We thank the staff of Fundación La Salle de Ciencias Naturales (FLASA), EDIMAR, Porlamar, Edo Nueva Esparta, Venezuela, and the crew of the R/V Hermano Ginés for their support during fieldwork for this study, especially Y. Astor and R. Varela. The fieldwork that provided samples and data for this study was supported by National Science Foundation (NSF) grants (OCE-1336082 to V.E. and OCE-1335436 and OCE-1259110 to G.T.T., Stony Brook University). Analysis of the data were partially supported by NSF grant OCE-19924492 to M.P. and V.E. and Simons Foundation award 929985 to M.P.
dc.identifier.citation	Geller-McGrath, D., Mara, P., Taylor, G., Suter, E., Edgcomb, V., & Pachiadaki, M. (2023). Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin. Nature Communications, 14(1), 656.
dc.identifier.doi	10.1038/s41467-023-36026-w
dc.identifier.uri	https://hdl.handle.net/1912/66877
dc.publisher	Nature Research
dc.relation.uri	https://doi.org/10.1038/s41467-023-36026-w
dc.rights	Attribution 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin
dc.type	Article
dspace.entity.type	Publication
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Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin

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